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MEDI524YTE.json
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MEDI524YTE.json
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"Seed": 1471738078,
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],
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},
"ExpressionProfiles": []
}
],
"Compounds": [
{
"Name": "MEDI524YTE",
"IsSmallMolecule": false,
"Lipophilicity": [
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"Name": "Measurement",
"Parameters": [
{
"Name": "Lipophilicity",
"Value": -5.0,
"Unit": "Log Units",
"ValueOrigin": {
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"Description": "/Dummy value not used in the simulation"
}
}
]
}
],
"FractionUnbound": [
{
"Name": "Measurement",
"Species": "Human",
"Parameters": [
{
"Name": "Fraction unbound (plasma, reference value)",
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"ValueOrigin": {
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}
}
]
}
],
"Solubility": [
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{
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"Unit": "mg/l",
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}
},
{
"Name": "Reference pH",
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"ValueOrigin": {
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}
}
]
}
],
"CalculationMethods": [
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"Cellular permeability - PK-Sim Standard"
],
"Parameters": [
{
"Name": "Molecular weight",
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"Unit": "g/mol",
"ValueOrigin": {
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}
},
{
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"Unit": "µm",
"ValueOrigin": {
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"Description": "Taylor1984"
}
},
{
"Name": "Kd (FcRn) in endosomal space",
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"Unit": "µmol/l",
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"Description": "Dall'Acqua2006"
}
}
]
}
],
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"DosingInterval": "Single",
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"Name": "Start time",
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"Unit": "h"
},
{
"Name": "InputDose",
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"Unit": "mg/kg"
},
{
"Name": "Infusion time",
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"Unit": "s"
}
]
}
],
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},
{
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},
{
"Name": "Resolution",
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"Unit": "pts/h"
}
]
},
{
"Parameters": [
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"Unit": "h"
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{
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}
},
{
"Name": "Resolution",
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}
]
}
],
"Parameters": [
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}
],
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],
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{
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