diff --git a/biolink-model.owl.ttl b/biolink-model.owl.ttl
index 99d8b97388..6b1feea8ca 100644
--- a/biolink-model.owl.ttl
+++ b/biolink-model.owl.ttl
@@ -10,10 +10,10 @@
     rdfs:label "Biolink-Model" ;
     dcterms:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
     skos:definition "Entity and association taxonomy and datamodel for life-sciences data" ;
-    meta:generation_date "2021-03-29 14:00" ;
+    meta:generation_date "2021-03-29 15:10" ;
     meta:metamodel_version "1.7.0" ;
     meta:source_file "biolink-model.yaml" ;
-    meta:source_file_date "Mon Mar 29 13:59:02 2021" ;
+    meta:source_file_date "Mon Mar 29 15:08:12 2021" ;
     meta:source_file_size 267798 .
 
 meta:SubsetDefinition a owl:Class ;
@@ -1319,6 +1319,10 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "case to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
@@ -1326,10 +1330,6 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
@@ -1397,20 +1397,20 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
     rdfs:label "disease to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
             owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/DiseaseToEntityAssociationMixin>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
@@ -1458,13 +1458,13 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "exposure event to outcome association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_population_context> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_temporal_context> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_population_context> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToOutcomeAssociationMixin>,
         <https://w3id.org/biolink/vocab/ExposureEventToEntityAssociationMixin> ;
@@ -1512,12 +1512,12 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genomic background exposure" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Gene> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_gene_or_gene_product> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Gene> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_gene_or_gene_product> ],
         <https://w3id.org/biolink/vocab/ExposureEvent>,
         <https://w3id.org/biolink/vocab/GeneGroupingMixin>,
         <https://w3id.org/biolink/vocab/GenomicEntity> ;
@@ -2733,10 +2733,6 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "cell line as a model of disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/CellLine> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
@@ -2748,6 +2744,10 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/CellLine> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/CellLineToDiseaseOrPhenotypicFeatureAssociation>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/ModelToDiseaseAssociationMixin> .
@@ -2922,25 +2922,25 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "exposure event to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/ExposureEvent> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
             owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/ExposureEvent> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." .
@@ -2950,20 +2950,20 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "frequency quantifier" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
         meta:mixin,
         <https://w3id.org/biolink/vocab/RelationshipQuantifier> .
 
@@ -2982,13 +2982,13 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene has variant that contributes to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
             owl:onProperty <https://w3id.org/biolink/vocab/sequence_variant_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/GeneToDiseaseAssociation> .
 
 <https://w3id.org/biolink/vocab/GeneToGeneCoexpressionAssociation> a owl:Class,
@@ -2998,10 +2998,6 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
             owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
@@ -3014,6 +3010,10 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
             owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/GeneExpressionMixin>,
         <https://w3id.org/biolink/vocab/GeneToGeneAssociation> ;
     skos:definition "Indicates that two genes are co-expressed, generally under the same conditions." .
@@ -3032,10 +3032,6 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
@@ -3047,6 +3043,10 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
@@ -3125,16 +3125,16 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "organismal entity as a model of disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
@@ -3200,24 +3200,24 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "variant to gene expression association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
         <https://w3id.org/biolink/vocab/GeneExpressionMixin>,
         <https://w3id.org/biolink/vocab/VariantToGeneAssociation> ;
     skos:definition "An association between a variant and expression of a gene (i.e. e-QTL)" .
@@ -3231,20 +3231,20 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
             owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin>,
         <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> .
@@ -4139,7 +4139,7 @@ meta:publication_type a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
@@ -4147,7 +4147,7 @@ meta:publication_type a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
         <https://w3id.org/biolink/vocab/Publication> .
 
 <https://w3id.org/biolink/vocab/BehaviorToBehavioralFeatureAssociation> a owl:Class,
@@ -4159,8 +4159,8 @@ meta:publication_type a owl:ObjectProperty,
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Behavior> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
@@ -4171,12 +4171,12 @@ meta:publication_type a owl:ObjectProperty,
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     skos:definition "An association between an aggregate behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." .
@@ -4192,11 +4192,11 @@ meta:publication_type a owl:ObjectProperty,
     rdfs:label "book" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/type> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/type> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Publication> ;
     skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .
@@ -4208,14 +4208,14 @@ meta:publication_type a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/chapter> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/published_in> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/published_in> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Publication> .
 
 <https://w3id.org/biolink/vocab/Case> a owl:Class,
@@ -4312,13 +4312,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "entity to feature or disease qualifiers mixin" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         meta:mixin,
         <https://w3id.org/biolink/vocab/FrequencyQualifierMixin> ;
     skos:definition "Qualifiers for entity to disease or phenotype associations." .
@@ -4384,13 +4384,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene to go term association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/FunctionalAssociation> ;
     skos:altLabel "functional association" .
 
@@ -4398,10 +4398,6 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
@@ -4409,18 +4405,22 @@ meta:publication_type a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin>,
         <https://w3id.org/biolink/vocab/GenotypeToEntityAssociationMixin> ;
@@ -4497,11 +4497,11 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "RNA product" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
         <https://w3id.org/biolink/vocab/GeneProductMixin>,
         <https://w3id.org/biolink/vocab/Transcript> .
 
@@ -4509,13 +4509,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "sequence variant modulates treatment association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Treatment> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Treatment> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
     skos:note "An alternate way to model the same information could be via a qualifier" .
@@ -4524,9 +4524,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "serial" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/issue> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/type> ;
@@ -4534,15 +4538,11 @@ meta:publication_type a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/issue> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
+            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
         <https://w3id.org/biolink/vocab/Publication> ;
     skos:altLabel "journal" ;
     skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .
@@ -4556,13 +4556,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "transcript to gene relationship" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Transcript> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Transcript> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/SequenceFeatureRelationship> ;
     skos:definition "A gene is a collection of transcripts" .
 
@@ -4896,10 +4896,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "anatomical entity to anatomical entity ontogenic association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
@@ -4907,6 +4903,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/AnatomicalEntityToAnatomicalEntityAssociation> ;
     skos:definition "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." .
 
@@ -4914,16 +4914,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "anatomical entity to anatomical entity part of association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/AnatomicalEntityToAnatomicalEntityAssociation> ;
     skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" .
@@ -4979,16 +4979,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
             owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
         meta:mixin ;
     skos:definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." .
 
@@ -5005,6 +5005,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene regulatory relationship" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
@@ -5012,10 +5016,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "A regulatory relationship between two genes" .
 
@@ -5024,20 +5024,20 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
     rdfs:label "gene to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/GeneToEntityAssociationMixin> ;
@@ -5056,13 +5056,13 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene to gene product relationship" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneProductMixin> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
@@ -5101,6 +5101,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to genotype part association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
@@ -5108,10 +5112,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between one genotype and a genotypic entity that is a sub-component of it" .
 
@@ -5122,14 +5122,14 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between a genotype and a sequence variant." .
 
@@ -5137,16 +5137,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "material sample derivation association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/MaterialSample> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/MaterialSample> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a material sample and the material entity from which it is derived." .
@@ -5175,10 +5175,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "organism taxon to environment association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
@@ -5186,6 +5182,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/OrganismTaxonToEntityAssociation> .
 
@@ -5193,16 +5193,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "organism taxon to organism taxon specialization" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/OrganismTaxonToOrganismTaxonAssociation> ;
     skos:definition "A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo" .
@@ -5244,6 +5244,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "population to population association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
@@ -5251,10 +5255,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a two populations" .
 
@@ -5262,11 +5262,11 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "protein" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         <https://w3id.org/biolink/vocab/GeneProductMixin>,
         <https://w3id.org/biolink/vocab/GenomicEntity> ;
     skos:altLabel "polypeptide" ;
@@ -5294,13 +5294,13 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "variant to gene association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
     skos:definition "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" .
@@ -5545,11 +5545,11 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:label "anatomical entity to anatomical entity association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> .
 
@@ -5559,12 +5559,12 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_output> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/PhysicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/enabled_by> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_input> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/PhysicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/enabled_by> ],
         <https://w3id.org/biolink/vocab/BiologicalEntity>,
         <https://w3id.org/biolink/vocab/Occurrent>,
         <https://w3id.org/biolink/vocab/OntologyClass> ;
@@ -5589,16 +5589,16 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "chemical to chemical derivation association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
             owl:onProperty <https://w3id.org/biolink/vocab/catalyst_qualifier> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
@@ -5617,16 +5617,16 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "contributor association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/InformationContentEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/OntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/qualifiers> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/InformationContentEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Agent> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
@@ -5638,6 +5638,10 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "dataset version" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Dataset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_dataset> ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/DatasetDistribution> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_distribution> ],
@@ -5645,10 +5649,6 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/ingest_date> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Dataset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_dataset> ],
         <https://w3id.org/biolink/vocab/InformationContentEntity> ;
     skos:definition "an item that holds version level information about a dataset." .
 
@@ -5658,6 +5658,13 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Attribute> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_attribute> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/type> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/category> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Agent> ;
             owl:onProperty <https://w3id.org/biolink/vocab/provided_by> ],
@@ -5667,27 +5674,20 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
+            owl:onClass <https://w3id.org/biolink/vocab/IriType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/iri> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/source> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/IriType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/iri> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/category> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/NarrativeText> ;
             owl:onProperty <https://w3id.org/biolink/vocab/description> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/type> ] ;
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ] ;
     skos:definition "Root Biolink Model class for all things and informational relationships, real or imagined." .
 
 <https://w3id.org/biolink/vocab/EntityToDiseaseOrPhenotypicFeatureAssociationMixin> a owl:Class,
@@ -5710,28 +5710,28 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
@@ -5779,11 +5779,11 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:label "organism taxon to organism taxon association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/OrganismTaxonToEntityAssociation> ;
@@ -5793,6 +5793,10 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "organism taxon to organism taxon interaction" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
@@ -5804,10 +5808,6 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/associated_environmental_context> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/OrganismTaxonToOrganismTaxonAssociation> ;
     skos:definition "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" .
 
@@ -5836,18 +5836,18 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "treatment" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Procedure> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_procedure> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Drug> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_drug> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Device> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_device> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Procedure> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_procedure> ],
         <https://w3id.org/biolink/vocab/ChemicalOrDrugOrTreatement>,
         <https://w3id.org/biolink/vocab/ExposureEvent>,
         <https://w3id.org/biolink/vocab/NamedThing> ;
@@ -5859,6 +5859,14 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "variant to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
@@ -5867,21 +5875,13 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
@@ -6022,10 +6022,6 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
@@ -6034,6 +6030,10 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a gene and an expression site, possibly qualified by stage/timing info." ;
     skos:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" .
@@ -6057,14 +6057,14 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "molecular activity" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_input> ],
+        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
             owl:onProperty <https://w3id.org/biolink/vocab/enabled_by> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_output> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_input> ],
         <https://w3id.org/biolink/vocab/BiologicalProcessOrActivity>,
         <https://w3id.org/biolink/vocab/Occurrent>,
         <https://w3id.org/biolink/vocab/OntologyClass> ;
@@ -6077,29 +6077,29 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "pairwise molecular interaction" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/interacting_molecules_category> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
             owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/interacting_molecules_category> ],
         <https://w3id.org/biolink/vocab/PairwiseGeneToGeneInteraction> ;
     skos:definition "An interaction at the molecular level between two physical entities" .
 
@@ -6130,33 +6130,33 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "variant to population association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/FrequencyQualifierMixin>,
         <https://w3id.org/biolink/vocab/FrequencyQuantifier>,
@@ -6247,13 +6247,13 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "functional association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." .
 
@@ -6415,37 +6415,37 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
         meta:ClassDefinition ;
     rdfs:label "genomic sequence localization" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/end_interbase_coordinate> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/strand> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/phase> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/start_interbase_coordinate> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/end_interbase_coordinate> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/strand> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/start_interbase_coordinate> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/genome_build> ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/phase> ],
+            owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/SequenceAssociation> ;
     skos:definition "A relationship between a sequence feature and a genomic entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." .
 
@@ -6533,20 +6533,20 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
         meta:ClassDefinition ;
     rdfs:label "agent" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/affiliation> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/address> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/affiliation> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/id> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         <https://w3id.org/biolink/vocab/AdministrativeEntity> ;
     skos:altLabel "group" ;
     skos:definition "person, group, organization or project that provides a piece of information (i.e. a knowledge association)" .
@@ -6669,21 +6669,21 @@ meta:topValue a owl:DatatypeProperty ;
         meta:ClassDefinition ;
     rdfs:label "information content entity" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Date> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/creation_date> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/rights> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/license> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/format> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Date> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/creation_date> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/format> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/license> ],
         <https://w3id.org/biolink/vocab/NamedThing> ;
     skos:altLabel "information",
         "information artefact",
@@ -6726,12 +6726,16 @@ meta:topValue a owl:DatatypeProperty ;
         meta:ClassDefinition ;
     rdfs:label "publication" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/summary> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/pages> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/authors> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
             owl:onProperty <https://w3id.org/biolink/vocab/mesh_terms> ],
@@ -6740,22 +6744,18 @@ meta:topValue a owl:DatatypeProperty ;
             owl:onProperty <https://w3id.org/biolink/vocab/type> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/authors> ],
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/summary> ],
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
+            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/pages> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/keywords> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         <https://w3id.org/biolink/vocab/InformationContentEntity> ;
     skos:definition "Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses." .
 
@@ -6774,14 +6774,14 @@ meta:topValue a owl:DatatypeProperty ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Gene> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_gene> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSequence> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_biological_sequence> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/GenomicEntity> ;
     skos:altLabel "allele" ;
     skos:definition "An allele that varies in its sequence from what is considered the reference allele at that locus." ;
@@ -6853,12 +6853,12 @@ meta:TypeDefinition a owl:Class ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/symbol> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         <https://w3id.org/biolink/vocab/GeneOrGeneProduct>,
         <https://w3id.org/biolink/vocab/GenomicEntity> ;
     skos:altLabel "locus" ;
@@ -6933,23 +6933,17 @@ meta:TypeDefinition a owl:Class ;
         meta:ClassDefinition ;
     rdfs:label "association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/qualifiers> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Boolean> ;
             owl:onProperty <https://w3id.org/biolink/vocab/negated> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Publication> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/publications> ],
+            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/category> ],
@@ -6958,13 +6952,19 @@ meta:TypeDefinition a owl:Class ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/type> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Publication> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/publications> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/qualifiers> ],
         <https://w3id.org/biolink/vocab/Entity> ;
     skos:definition "A typed association between two entities, supported by evidence" ;
     skos:note "This is roughly the model used by biolink and ontobio at the moment" .
diff --git a/biolink-model.ttl b/biolink-model.ttl
index 054108cd31..cabe3d1943 100644
--- a/biolink-model.ttl
+++ b/biolink-model.ttl
@@ -15,7 +15,7 @@
 
 <https://w3id.org/biolink/vocab/Biolink-Model> a metatype:SchemaDefinition ;
     dcterms:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
-    pav:version "1.6.1" ;
+    pav:version "1.7.0" ;
     skos:definition "Entity and association taxonomy and datamodel for life-sciences data" ;
     meta:classes <https://w3id.org/biolink/vocab/Activity>,
         <https://w3id.org/biolink/vocab/ActivityAndBehavior>,
@@ -264,201 +264,201 @@
         <https://w3id.org/biolink/vocab/Zygosity> ;
     meta:default_range <https://w3id.org/biolink/vocab/string> ;
     meta:enums <https://w3id.org/biolink/vocab/logical_interpretation_enum> ;
-    meta:generation_date "2021-03-29 14:01"^^xsd:dateTime ;
+    meta:generation_date "2021-03-29 15:10"^^xsd:dateTime ;
     meta:id <https://w3id.org/biolink/biolink-model> ;
     meta:imports biolinkml:types ;
-    meta:prefixes [ meta:prefix_reference <http://edamontology.org/format_> ;
-            metatype:prefix_prefix "EDAM-FORMAT" ],
-        [ meta:prefix_reference <https://metamap.nlm.nih.gov/Docs/SemGroups_2018.txt/group#> ;
-            metatype:prefix_prefix "UMLSSG" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/MetaCyc_> ;
-            metatype:prefix_prefix "MetaCyc" ],
-        [ meta:prefix_reference <http://chembank.broadinstitute.org/chemistry/viewMolecule.htm?cbid=> ;
-            metatype:prefix_prefix "ChemBank" ],
-        [ meta:prefix_reference <https://orcid.org/> ;
-            metatype:prefix_prefix "ORCID" ],
-        [ meta:prefix_reference <http://pubchem.ncbi.nlm.nih.gov/compound/> ;
-            metatype:prefix_prefix "CID" ],
-        [ meta:prefix_reference <http://www.geneontology.org/formats/oboInOWL#> ;
-            metatype:prefix_prefix "oboformat" ],
-        [ meta:prefix_reference pav: ;
-            metatype:prefix_prefix "pav" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/go#> ;
-            metatype:prefix_prefix "GOP" ],
-        [ meta:prefix_reference <https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=> ;
-            metatype:prefix_prefix "RXCUI" ],
-        [ meta:prefix_reference <http://edamontology.org/data_> ;
-            metatype:prefix_prefix "EDAM-DATA" ],
-        [ meta:prefix_reference <https://isni.org/isni/> ;
-            metatype:prefix_prefix "isni" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/chembio_> ;
-            metatype:prefix_prefix "chembio" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/Aeolus_> ;
-            metatype:prefix_prefix "Aeolus" ],
-        [ meta:prefix_reference <http://purl.bioontology.org/ontology/NDDF/> ;
-            metatype:prefix_prefix "NDDF" ],
-        [ meta:prefix_reference <http://apps.chiragjpgroup.org/repoDB/> ;
-            metatype:prefix_prefix "REPODB" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/hetio_> ;
-            metatype:prefix_prefix "hetio" ],
-        [ meta:prefix_reference <http://purl.org/spar/fabio/> ;
-            metatype:prefix_prefix "fabio" ],
-        [ meta:prefix_reference <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/type#> ;
-            metatype:prefix_prefix "UMLSST" ],
-        [ meta:prefix_reference <https://www.dgidb.org/interaction_types> ;
-            metatype:prefix_prefix "DGIdb" ],
-        [ meta:prefix_reference <http://www.orpha.net/ORDO/Orphanet_> ;
-            metatype:prefix_prefix "ORPHA" ],
-        [ meta:prefix_reference <https://scholar.google.com/citations?user=> ;
-            metatype:prefix_prefix "GSID" ],
-        [ meta:prefix_reference <http://www.w3.org/2003/01/geo/wgs84_pos> ;
-            metatype:prefix_prefix "wgs" ],
-        [ meta:prefix_reference <http://gmod.org/wiki/Chado/> ;
-            metatype:prefix_prefix "CHADO" ],
-        [ meta:prefix_reference <http://www.w3.org/ns/prov#> ;
-            metatype:prefix_prefix "prov" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/GOREL_> ;
-            metatype:prefix_prefix "GOREL" ],
-        [ meta:prefix_reference <https://www.gsea-msigdb.org/gsea/msigdb/> ;
-            metatype:prefix_prefix "MSigDB" ],
-        [ meta:prefix_reference <https://www.gtexportal.org/home/gene/> ;
-            metatype:prefix_prefix "GTEx" ],
+    meta:prefixes [ meta:prefix_reference <http://purl.bioontology.org/ontology/RXNORM/> ;
+            metatype:prefix_prefix "RXNORM" ],
+        [ meta:prefix_reference <http://kg1endpoint.rtx.ai/> ;
+            metatype:prefix_prefix "RTXKG1" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/RO_> ;
+            metatype:prefix_prefix "OBOREL" ],
+        [ meta:prefix_reference <http://edamontology.org/topic_> ;
+            metatype:prefix_prefix "EDAM-TOPIC" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/uberon/core#> ;
+            metatype:prefix_prefix "UBERON_CORE" ],
+        [ meta:prefix_reference <https://www.ebi.ac.uk/interpro/entry/> ;
+            metatype:prefix_prefix "interpro" ],
+        [ meta:prefix_reference <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> ;
+            metatype:prefix_prefix "gff3" ],
         [ meta:prefix_reference <http://purl.obolibrary.org/obo/ECTO_> ;
             metatype:prefix_prefix "ECTO" ],
-        [ meta:prefix_reference <https://www.ncbi.nlm.nih.gov/nlmcatalog/?term=> ;
-            metatype:prefix_prefix "NLMID" ],
-        [ meta:prefix_reference <https://skr3.nlm.nih.gov/SemMedDB> ;
-            metatype:prefix_prefix "SEMMEDDB" ],
+        [ meta:prefix_reference <http://translator.renci.org/GAMMA_> ;
+            metatype:prefix_prefix "GAMMA" ],
         [ meta:prefix_reference <https://www.ncbi.nlm.nih.gov/medgen/> ;
             metatype:prefix_prefix "medgen" ],
-        [ meta:prefix_reference <http://purl.bioontology.org/ontology/RXNORM/> ;
-            metatype:prefix_prefix "RXNORM" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD0_> ;
-            metatype:prefix_prefix "ICD0" ],
         [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
             metatype:prefix_prefix "KEGG.BRITE" ],
-        [ meta:prefix_reference <https://www.wikidata.org/wiki/Property:> ;
-            metatype:prefix_prefix "WIKIDATA_PROPERTY" ],
-        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
-            metatype:prefix_prefix "KEGG.DGROUP" ],
-        [ meta:prefix_reference <http://qudt.org/1.1/schema/qudt#> ;
-            metatype:prefix_prefix "qud" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD9_> ;
-            metatype:prefix_prefix "ICD9" ],
-        [ meta:prefix_reference <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> ;
-            metatype:prefix_prefix "os" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/DrugCentral_> ;
-            metatype:prefix_prefix "DrugCentral" ],
-        [ meta:prefix_reference <http://loinc.org/rdf/> ;
-            metatype:prefix_prefix "LOINC" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/uberon/core#> ;
-            metatype:prefix_prefix "UBERON_CORE" ],
-        [ meta:prefix_reference <https://www.alliancegenome.org/> ;
-            metatype:prefix_prefix "alliancegenome" ],
+        [ meta:prefix_reference <https://www.wikidata.org/wiki/> ;
+            metatype:prefix_prefix "WIKIDATA" ],
         [ meta:prefix_reference <https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=> ;
             metatype:prefix_prefix "GTOPDB" ],
-        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD10_> ;
-            metatype:prefix_prefix "ICD10" ],
-        [ meta:prefix_reference <https://www.cancer.gov/publications/pdq#> ;
-            metatype:prefix_prefix "PDQ" ],
+        [ meta:prefix_reference <http://www.geneontology.org/formats/oboInOWL#> ;
+            metatype:prefix_prefix "oboformat" ],
+        [ meta:prefix_reference schema: ;
+            metatype:prefix_prefix "schema" ],
         [ meta:prefix_reference <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/code#> ;
             metatype:prefix_prefix "UMLSSC" ],
-        [ meta:prefix_reference <https://w3id.org/biolink/vocab/> ;
-            metatype:prefix_prefix "biolink" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/HsapDv_> ;
-            metatype:prefix_prefix "HsapDv" ],
-        [ meta:prefix_reference <http://translator.renci.org/GAMMA_> ;
-            metatype:prefix_prefix "GAMMA" ],
-        [ meta:prefix_reference <http://bio2rdf.org/wormbase_vocabulary> ;
-            metatype:prefix_prefix "WBVocab" ],
-        [ meta:prefix_reference <http://semanticscience.org/resource/SIO_> ;
-            metatype:prefix_prefix "SIO" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/DrugCentral_> ;
+            metatype:prefix_prefix "DrugCentral" ],
+        [ meta:prefix_reference <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> ;
+            metatype:prefix_prefix "os" ],
         [ meta:prefix_reference <http://www.ebi.ac.uk/ancestro/ancestro_> ;
             metatype:prefix_prefix "HANCESTRO" ],
-        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
-            metatype:prefix_prefix "KEGG.RCLASS" ],
-        [ meta:prefix_reference <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> ;
-            metatype:prefix_prefix "VANDF" ],
-        [ meta:prefix_reference <http://pharos.nih.gov/> ;
-            metatype:prefix_prefix "PHAROS" ],
-        [ meta:prefix_reference <https://www.ebi.ac.uk/interpro/entry/> ;
-            metatype:prefix_prefix "interpro" ],
-        [ meta:prefix_reference <https://doi.org/> ;
-            metatype:prefix_prefix "doi" ],
-        [ meta:prefix_reference schema: ;
-            metatype:prefix_prefix "schema" ],
+        [ meta:prefix_reference <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> ;
+            metatype:prefix_prefix "gpi" ],
         [ meta:prefix_reference <http://translator.ncats.nih.gov/SNPEFF_> ;
             metatype:prefix_prefix "SNPEFF" ],
+        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
+            metatype:prefix_prefix "KEGG.ENZYME" ],
+        [ meta:prefix_reference <http://xmlns.com/foaf/0.1/> ;
+            metatype:prefix_prefix "foaf" ],
         [ meta:prefix_reference <http://purl.obolibrary.org/obo/INO_> ;
             metatype:prefix_prefix "INO" ],
-        [ meta:prefix_reference <http://translator.renci.org/ubergraph-axioms.ofn#> ;
-            metatype:prefix_prefix "UBERGRAPH" ],
-        [ meta:prefix_reference <http://kg1endpoint.rtx.ai/> ;
-            metatype:prefix_prefix "RTXKG1" ],
-        [ meta:prefix_reference <http://edamontology.org/topic_> ;
-            metatype:prefix_prefix "EDAM-TOPIC" ],
-        [ meta:prefix_reference <http://smpdb.ca/pathways/#> ;
-            metatype:prefix_prefix "PathWhiz" ],
-        [ meta:prefix_reference <http://foodb.ca/compounds/> ;
-            metatype:prefix_prefix "foodb.compound" ],
+        [ meta:prefix_reference <http://bio2rdf.org/wormbase_vocabulary> ;
+            metatype:prefix_prefix "WBVocab" ],
+        [ meta:prefix_reference <https://metamap.nlm.nih.gov/Docs/SemanticTypes_2018AB.txt/type#> ;
+            metatype:prefix_prefix "UMLSST" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/go#> ;
+            metatype:prefix_prefix "GOP" ],
+        [ meta:prefix_reference <https://www.scopus.com/authid/detail.uri?authorId=> ;
+            metatype:prefix_prefix "ScopusID" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/MI_> ;
+            metatype:prefix_prefix "MI" ],
+        [ meta:prefix_reference biolinkml: ;
+            metatype:prefix_prefix "biolinkml" ],
+        [ meta:prefix_reference <https://www.dgidb.org/interaction_types> ;
+            metatype:prefix_prefix "DGIdb" ],
+        [ meta:prefix_reference <http://purl.org/coar/resource_type/> ;
+            metatype:prefix_prefix "COAR_RESOURCE" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/pato#> ;
+            metatype:prefix_prefix "PATO-PROPERTY" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD10_> ;
+            metatype:prefix_prefix "ICD10" ],
         [ meta:prefix_reference <http://purl.bioontology.org/ontology/HCPCS/> ;
             metatype:prefix_prefix "HCPCS" ],
-        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
-            metatype:prefix_prefix "KEGG.ENZYME" ],
+        [ meta:prefix_reference <https://www.cancer.gov/publications/pdq#> ;
+            metatype:prefix_prefix "PDQ" ],
+        [ meta:prefix_reference <http://edamontology.org/format_> ;
+            metatype:prefix_prefix "EDAM-FORMAT" ],
+        [ meta:prefix_reference <https://portal.issn.org/resource/ISSN/> ;
+            metatype:prefix_prefix "issn" ],
         [ meta:prefix_reference <https://rdf.guidetopharmacology.org/ns/gtpo#> ;
             metatype:prefix_prefix "gtpo" ],
+        [ meta:prefix_reference <http://edamontology.org/operation_> ;
+            metatype:prefix_prefix "EDAM-OPERATION" ],
+        [ meta:prefix_reference <https://www.alliancegenome.org/> ;
+            metatype:prefix_prefix "alliancegenome" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/ExO_> ;
+            metatype:prefix_prefix "ExO" ],
+        [ meta:prefix_reference <http://www.w3.org/2003/01/geo/wgs84_pos> ;
+            metatype:prefix_prefix "wgs" ],
+        [ meta:prefix_reference <http://semanticscience.org/resource/SIO_> ;
+            metatype:prefix_prefix "SIO" ],
+        [ meta:prefix_reference <http://edamontology.org/data_> ;
+            metatype:prefix_prefix "EDAM-DATA" ],
+        [ meta:prefix_reference <http://foodb.ca/compounds/> ;
+            metatype:prefix_prefix "foodb.compound" ],
+        [ meta:prefix_reference <http://qudt.org/1.1/schema/qudt#> ;
+            metatype:prefix_prefix "qud" ],
+        [ meta:prefix_reference <https://w3id.org/biolink/vocab/> ;
+            metatype:prefix_prefix "biolink" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD9_> ;
+            metatype:prefix_prefix "ICD9" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/GOREL_> ;
+            metatype:prefix_prefix "GOREL" ],
         [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
-            metatype:prefix_prefix "KEGG.GENE" ],
+            metatype:prefix_prefix "KEGG.RCLASS" ],
+        [ meta:prefix_reference <http://gmod.org/wiki/Chado/> ;
+            metatype:prefix_prefix "CHADO" ],
+        [ meta:prefix_reference <https://www.ncbi.nlm.nih.gov/nlmcatalog/?term=> ;
+            metatype:prefix_prefix "NLMID" ],
+        [ meta:prefix_reference <http://loinc.org/rdf/> ;
+            metatype:prefix_prefix "LOINC" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/ICD0_> ;
+            metatype:prefix_prefix "ICD0" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/hetio_> ;
+            metatype:prefix_prefix "hetio" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/Aeolus_> ;
+            metatype:prefix_prefix "Aeolus" ],
         [ meta:prefix_reference dcterms: ;
             metatype:prefix_prefix "dct" ],
-        [ meta:prefix_reference <http://purl.org/oban/> ;
-            metatype:prefix_prefix "OBAN" ],
-        [ meta:prefix_reference <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> ;
-            metatype:prefix_prefix "gpi" ],
-        [ meta:prefix_reference <https://www.scopus.com/authid/detail.uri?authorId=> ;
-            metatype:prefix_prefix "ScopusID" ],
-        [ meta:prefix_reference <http://edamontology.org/operation_> ;
-            metatype:prefix_prefix "EDAM-OPERATION" ],
+        [ meta:prefix_reference <http://apps.chiragjpgroup.org/repoDB/> ;
+            metatype:prefix_prefix "REPODB" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/MetaCyc_> ;
+            metatype:prefix_prefix "MetaCyc" ],
         [ meta:prefix_reference <http://www.ebi.ac.uk/efo/EFO_> ;
             metatype:prefix_prefix "EFO" ],
-        [ meta:prefix_reference <https://portal.issn.org/resource/ISSN/> ;
-            metatype:prefix_prefix "issn" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/RO_> ;
-            metatype:prefix_prefix "RO" ],
-        [ meta:prefix_reference <https://github.com/ga4gh/vr-spec/> ;
-            metatype:prefix_prefix "VMC" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/MI_> ;
-            metatype:prefix_prefix "MI" ],
-        [ meta:prefix_reference <https://publons.com/researcher/> ;
-            metatype:prefix_prefix "ResearchID" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/RO_> ;
-            metatype:prefix_prefix "OBOREL" ],
+        [ meta:prefix_reference <http://translator.ncats.nih.gov/chembio_> ;
+            metatype:prefix_prefix "chembio" ],
+        [ meta:prefix_reference <https://orcid.org/> ;
+            metatype:prefix_prefix "ORCID" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/HsapDv_> ;
+            metatype:prefix_prefix "HsapDv" ],
+        [ meta:prefix_reference <http://purl.org/spar/fabio/> ;
+            metatype:prefix_prefix "fabio" ],
+        [ meta:prefix_reference <https://metamap.nlm.nih.gov/Docs/SemGroups_2018.txt/group#> ;
+            metatype:prefix_prefix "UMLSSG" ],
+        [ meta:prefix_reference <http://chembank.broadinstitute.org/chemistry/viewMolecule.htm?cbid=> ;
+            metatype:prefix_prefix "ChemBank" ],
+        [ meta:prefix_reference <https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=> ;
+            metatype:prefix_prefix "RXCUI" ],
+        [ meta:prefix_reference pav: ;
+            metatype:prefix_prefix "pav" ],
+        [ meta:prefix_reference <https://www.ebi.ac.uk/chembl/mechanism/inspect/> ;
+            metatype:prefix_prefix "CHEMBL.MECHANISM" ],
+        [ meta:prefix_reference <http://www.w3.org/ns/prov#> ;
+            metatype:prefix_prefix "prov" ],
+        [ meta:prefix_reference <https://www.wikidata.org/wiki/Property:> ;
+            metatype:prefix_prefix "WIKIDATA_PROPERTY" ],
+        [ meta:prefix_reference <http://www.orpha.net/ORDO/Orphanet_> ;
+            metatype:prefix_prefix "ORPHA" ],
+        [ meta:prefix_reference <https://www.gtexportal.org/home/gene/> ;
+            metatype:prefix_prefix "GTEx" ],
+        [ meta:prefix_reference <http://purl.bioontology.org/ontology/NDDF/> ;
+            metatype:prefix_prefix "NDDF" ],
+        [ meta:prefix_reference <https://isni.org/isni/> ;
+            metatype:prefix_prefix "isni" ],
         [ meta:prefix_reference <http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_caid?caid=> ;
             metatype:prefix_prefix "CAID" ],
-        [ meta:prefix_reference <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> ;
-            metatype:prefix_prefix "gff3" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/ExO_> ;
-            metatype:prefix_prefix "ExO" ],
-        [ meta:prefix_reference <https://www.wikidata.org/wiki/> ;
-            metatype:prefix_prefix "WIKIDATA" ],
-        [ meta:prefix_reference <https://www.ama-assn.org/practice-management/cpt/> ;
-            metatype:prefix_prefix "CPT" ],
-        [ meta:prefix_reference biolinkml: ;
-            metatype:prefix_prefix "biolinkml" ],
-        [ meta:prefix_reference <http://xmlns.com/foaf/0.1/> ;
-            metatype:prefix_prefix "foaf" ],
+        [ meta:prefix_reference <http://pubchem.ncbi.nlm.nih.gov/compound/> ;
+            metatype:prefix_prefix "CID" ],
+        [ meta:prefix_reference <https://doi.org/> ;
+            metatype:prefix_prefix "doi" ],
+        [ meta:prefix_reference <https://scholar.google.com/citations?user=> ;
+            metatype:prefix_prefix "GSID" ],
+        [ meta:prefix_reference <http://purl.org/oban/> ;
+            metatype:prefix_prefix "OBAN" ],
+        [ meta:prefix_reference <http://pharos.nih.gov/> ;
+            metatype:prefix_prefix "PHAROS" ],
+        [ meta:prefix_reference <http://translator.renci.org/ubergraph-axioms.ofn#> ;
+            metatype:prefix_prefix "UBERGRAPH" ],
+        [ meta:prefix_reference <http://smpdb.ca/pathways/#> ;
+            metatype:prefix_prefix "PathWhiz" ],
+        [ meta:prefix_reference <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> ;
+            metatype:prefix_prefix "VANDF" ],
         [ meta:prefix_reference <http://translator.ncats.nih.gov/CTD_> ;
             metatype:prefix_prefix "CTD" ],
+        [ meta:prefix_reference <http://purl.obolibrary.org/obo/RO_> ;
+            metatype:prefix_prefix "RO" ],
+        [ meta:prefix_reference <https://publons.com/researcher/> ;
+            metatype:prefix_prefix "ResearchID" ],
+        [ meta:prefix_reference <https://www.isbn-international.org/identifier/> ;
+            metatype:prefix_prefix "isbn" ],
         [ meta:prefix_reference <http://www.w3.org/ns/dcat#> ;
             metatype:prefix_prefix "dcat" ],
-        [ meta:prefix_reference <http://purl.org/coar/resource_type/> ;
-            metatype:prefix_prefix "COAR_RESOURCE" ],
-        [ meta:prefix_reference <http://purl.obolibrary.org/obo/pato#> ;
-            metatype:prefix_prefix "PATO-PROPERTY" ],
-        [ meta:prefix_reference <https://www.ebi.ac.uk/chembl/mechanism/inspect/> ;
-            metatype:prefix_prefix "CHEMBL.MECHANISM" ],
-        [ meta:prefix_reference <https://www.isbn-international.org/identifier/> ;
-            metatype:prefix_prefix "isbn" ] ;
+        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
+            metatype:prefix_prefix "KEGG.DGROUP" ],
+        [ meta:prefix_reference <https://www.gsea-msigdb.org/gsea/msigdb/> ;
+            metatype:prefix_prefix "MSigDB" ],
+        [ meta:prefix_reference <https://www.ama-assn.org/practice-management/cpt/> ;
+            metatype:prefix_prefix "CPT" ],
+        [ meta:prefix_reference <https://github.com/ga4gh/vr-spec/> ;
+            metatype:prefix_prefix "VMC" ],
+        [ meta:prefix_reference <http://www.kegg.jp/entry/> ;
+            metatype:prefix_prefix "KEGG.GENE" ],
+        [ meta:prefix_reference <https://skr3.nlm.nih.gov/SemMedDB> ;
+            metatype:prefix_prefix "SEMMEDDB" ] ;
     meta:slots <https://w3id.org/biolink/vocab/actively_involved_in>,
         <https://w3id.org/biolink/vocab/address>,
         <https://w3id.org/biolink/vocab/affected_by>,
@@ -934,7 +934,7 @@
         <https://w3id.org/biolink/vocab/volume>,
         <https://w3id.org/biolink/vocab/xenologous_to>,
         <https://w3id.org/biolink/vocab/xref> ;
-    meta:source_file_date "Mon Mar 29 13:59:02 2021"^^xsd:dateTime ;
+    meta:source_file_date "Mon Mar 29 15:08:12 2021"^^xsd:dateTime ;
     meta:source_file_size 267798 ;
     meta:subsets <https://w3id.org/biolink/vocab/model_organism_database>,
         <https://w3id.org/biolink/vocab/samples>,
@@ -1541,10 +1541,10 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeatureToEntityAssociationMixin> ;
     meta:domain_of <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeatureToEntityAssociationMixin> ;
-    meta:examples [ skos:definition "Ehlers-Danlos syndrome, vascular type" ;
-            skos:example "MONDO:0017314" ],
-        [ skos:definition "abnormal brain ventricle size" ;
-            skos:example "MP:0013229" ] ;
+    meta:examples [ skos:definition "abnormal brain ventricle size" ;
+            skos:example "MP:0013229" ],
+        [ skos:definition "Ehlers-Danlos syndrome, vascular type" ;
+            skos:example "MONDO:0017314" ] ;
     meta:is_a <https://w3id.org/biolink/vocab/subject> ;
     meta:is_usage_slot true ;
     meta:owner <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeatureToEntityAssociationMixin> ;
@@ -1641,10 +1641,10 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/EntityToDiseaseOrPhenotypicFeatureAssociationMixin> ;
     meta:domain_of <https://w3id.org/biolink/vocab/EntityToDiseaseOrPhenotypicFeatureAssociationMixin> ;
-    meta:examples [ skos:definition "Ehlers-Danlos syndrome, vascular type" ;
-            skos:example "MONDO:0017314" ],
-        [ skos:definition "abnormal brain ventricle size" ;
-            skos:example "MP:0013229" ] ;
+    meta:examples [ skos:definition "abnormal brain ventricle size" ;
+            skos:example "MP:0013229" ],
+        [ skos:definition "Ehlers-Danlos syndrome, vascular type" ;
+            skos:example "MONDO:0017314" ] ;
     meta:is_a <https://w3id.org/biolink/vocab/object> ;
     meta:is_usage_slot true ;
     meta:owner <https://w3id.org/biolink/vocab/EntityToDiseaseOrPhenotypicFeatureAssociationMixin> ;
@@ -1700,12 +1700,12 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     meta:domain_of <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
-    meta:examples [ skos:definition "abnormal circulating bilirubin level" ;
-            skos:example "MP:0001569" ],
-        [ skos:definition "Hyperkinesis" ;
+    meta:examples [ skos:definition "Hyperkinesis" ;
             skos:example "HP:0002487" ],
         [ skos:definition "axon morphology variant" ;
-            skos:example "WBPhenotype:0000180" ] ;
+            skos:example "WBPhenotype:0000180" ],
+        [ skos:definition "abnormal circulating bilirubin level" ;
+            skos:example "MP:0001569" ] ;
     meta:is_a <https://w3id.org/biolink/vocab/object> ;
     meta:is_usage_slot true ;
     meta:owner <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
@@ -7674,11 +7674,11 @@
     meta:inherited true ;
     meta:is_a <https://w3id.org/biolink/vocab/entity_regulates_entity> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "positively regulates" ;
-            metatype:local_name_source "translator" ],
-        [ a metatype:LocalName ;
             skos:altLabel "activity directly positively regulates activity of" ;
-            metatype:local_name_source "ro" ] ;
+            metatype:local_name_source "ro" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "positively regulates" ;
+            metatype:local_name_source "translator" ] ;
     meta:mixins <https://w3id.org/biolink/vocab/positively_regulates> ;
     meta:multivalued true ;
     meta:owner <https://w3id.org/biolink/vocab/entity_positively_regulates_entity> ;
@@ -10297,11 +10297,11 @@
     meta:inherited true ;
     meta:is_a <https://w3id.org/biolink/vocab/affects> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "activity directly regulates activity of" ;
-            metatype:local_name_source "ro" ],
-        [ a metatype:LocalName ;
             skos:altLabel "regulates" ;
-            metatype:local_name_source "translator" ] ;
+            metatype:local_name_source "translator" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "activity directly regulates activity of" ;
+            metatype:local_name_source "ro" ] ;
     meta:mixins <https://w3id.org/biolink/vocab/regulates> ;
     meta:multivalued true ;
     meta:owner <https://w3id.org/biolink/vocab/entity_regulates_entity> ;
@@ -13651,11 +13651,11 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     skos:note "This class is for modeling the specific state at a locus. A single DBSNP rs ID could correspond to more than one sequence variants (e.g CIViC:1252 and CIViC:1253, two distinct BRCA2 alleles for rs28897743)" ;
     meta:alt_descriptions [ a metatype:AltDescription ;
-            skos:definition "An entity that describes a single affected, endogenous allele. These can be of any type that matches that definition" ;
-            metatype:source "AGR" ],
-        [ a metatype:AltDescription ;
             skos:definition "A contiguous change at a Location" ;
-            metatype:source "VMC" ] ;
+            metatype:source "VMC" ],
+        [ a metatype:AltDescription ;
+            skos:definition "An entity that describes a single affected, endogenous allele. These can be of any type that matches that definition" ;
+            metatype:source "AGR" ] ;
     meta:class_uri <https://w3id.org/biolink/vocab/SequenceVariant> ;
     meta:definition_uri <https://w3id.org/biolink/vocab/SequenceVariant> ;
     meta:is_a <https://w3id.org/biolink/vocab/GenomicEntity> ;
@@ -14120,11 +14120,11 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
     meta:domain_of <https://w3id.org/biolink/vocab/Association> ;
     meta:is_a <https://w3id.org/biolink/vocab/association_slot> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "predicate" ;
-            metatype:local_name_source "translator" ],
-        [ a metatype:LocalName ;
             skos:altLabel "annotation predicate" ;
-            metatype:local_name_source "ga4gh" ] ;
+            metatype:local_name_source "ga4gh" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "predicate" ;
+            metatype:local_name_source "translator" ] ;
     meta:owner <https://w3id.org/biolink/vocab/Association> ;
     meta:range <https://w3id.org/biolink/vocab/predicate_type> ;
     meta:required true ;
diff --git a/biolink/model.py b/biolink/model.py
index fcd43e2d3c..8cf14f6b36 100644
--- a/biolink/model.py
+++ b/biolink/model.py
@@ -1,5 +1,5 @@
 # Auto generated from biolink-model.yaml by pythongen.py version: 0.9.0
-# Generation date: 2021-03-29 14:01
+# Generation date: 2021-03-29 15:10
 # Schema: Biolink-Model
 #
 # id: https://w3id.org/biolink/biolink-model
diff --git a/context.jsonld b/context.jsonld
index 4c9292c258..7138505048 100644
--- a/context.jsonld
+++ b/context.jsonld
@@ -1,5 +1,5 @@
 {
-   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-29 14:00\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
+   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-29 15:10\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
    "@context": {
       "type": {
          "@id": "rdf:type"
diff --git a/contextn.jsonld b/contextn.jsonld
index 29c7e30622..a80a301c66 100644
--- a/contextn.jsonld
+++ b/contextn.jsonld
@@ -1,5 +1,5 @@
 {
-   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-29 14:00\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
+   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-29 15:10\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
    "@context": {
       "type": "@type",
       "APO": "http://purl.obolibrary.org/obo/APO_",