CYP3A4_mod_substrates

generic_drug_name,notes,cyp_strength_of_evidence,drug_class,adverse_drug_reactions,first_ref,second_ref,date_checked
diazepam,n/a,mod,benzodiazepines,"somnolence^^, ataxia^, anterograde_amnesia^, disrupted_sensory_perception(ws)^, dizziness^, drowsiness^, fatique^, general_malaise(ws)^, epileptic_attacks^, impaired_motor_ability^, tremor(ws)^, convulsion^, dysarthria^, epileptic_attacks (ws)^, headache^, impaired_motor_ability^, incoordination^, speech_disorder^, vertigo^, aggression(ws)^, anxiety(ws)^, confusion^, delirium(ws)^, irritability(ws)^, panic(ws)^, paranoid_psychosis(ws)^, withdrawal_symptoms^, asthma^, hiccup^, rhinitis^, hypotension^, palpitations(ws)^, vasodilation^, muscle_spasms(ws)^, muscle_weakness^, GI_disorders(ws)^, loss_of_appetite(ws)^, sweating(ws)^, rash^, double_vision/diplopia(rectal)^",drugs.com,nzf,291124
hydrocortisone,n/a,mod,corticosteroids,"hypothalamus_pituitary_adrenal_activity_suppression(dd), Cushingoid_appearance(dd), hirsutism(dd), impotence(dd), menstrual_irregularities(dd), peptic_ulcer_disease(dd), cataracts(dd), increased_intraocular_pressure/glaucoma(dd), myopathy(dd), osteoporosis(dd), vertebral_compression_fractures(dd), sodium_retention_related_weight_gain_and_fluid_accumulation(dd), hyperglycemia/glucose_intolerance(dd), hypokalemia(dd), psychic_disturbances(dd)",drugs.com,nzf,291124
lansoprazole,n/a,mod,proton_pump_inhibitors,"abdominal_pain^, benign_fundic_gland_polyps^, constipation^, diarrhea^, dry_mouth^, flatulence^, stomach_ache^, itching^, pruritus^, rash^, urticaria^, fatal_toxic_epidermal_necrolysis(pm), dizziness^, headache^, taste_disturbance^, speech_disorder(pm), increased_liver_enzyme_levels^, hepatotoxicity(pm), fatigue^, dry_throat^, myositis(pm), aplastic_anemia(pm), hemolytic_anemia(pm), thrombotic_thrombocytopenic_purpura(pm), anaphylactoid_reactions(pm)",drugs.com,nzf,291124
pantoprazole,n/a,mod,proton_pump_inhibitors,"headache^^, taste_disturbance^^, nasopharyngitis^^, pharyngolaryngeal_pain^^, diarrhea^^, dizziness^, metallic/bitter_taste^, somnolence^, ageusia(pm), taste_disturbance(pm), cough^, nasal_congestion^, pharyngitis^, abdominal_pain^, benign_fundic_gland_polyps^, buccal_inflammation^, constipation^, dry_mouth^, dyspepsia^, fecal_discoloration^, flatulence^, heartburn^, oral_thrush^, pruritus^, tongue_discoloration^, tongue_pain^, upper_abdominal_pain^, tiredness^, depression^, insomnia(pm), increased_liver_enzymes^, hepatocellular_damage(pm), rash^, chest_pain^, arthralgia^, rhabdomyolysis(pm), anorexia^, influenza_like_symptoms^, candidal_infection^, anaphylaxis(pm)",drugs.com,nzf,031224
lercanidipine,*,mod,calcium_channel_blockers,"hypotension(pm), gingival_hypertrophy(pm), urinary_frequency(pm), chest_pain(pm), increased_liver_enzymes(pm)",drugs.com,drugs.com_uk_di,031224
naldemedine,n/a,mod,peripheral_opioid_receptor_antagonists,"diarrhea^^, abdominal_pain^^, gastroenteritis^, bronchospasm(pm), rash(pm)",drugs.com,Drugs@FDA,061224
nelfinavir,n/a,mod,antivirals,"diarrhea^^, flatulence^, decreased_lymphocytes^, decreased_neutrophils^, decreased_hemoglobin^, elevated_AST^, elevated_ALT^, jaundice(pm), bilirubinemia(pm), elevated_creatine_kinase^, rash^, QTc_prolongation(pm), torsades_de_pointes(pm), metabolic_acidosis(pm), new_onset_diabetes_mellitus(pm_HIV_pit), exacerbation_of_pre_existing_diabetes_mellitus(pm_HIV_pit), hyperglycemia(pm_HIV_pit), ketoacidosis(pm_HIV_pit), hypersensitivity_reactions(pm)",drugs.com,Drugs@FDA,061224
telaprevir,*,mod,antivirals,"rash^^, pruritus^^, anemia^^, decreased_mean_platelet_counts^^, decreased_hemoglobin_levels^^, decreased_lymphocyte_counts^^, decreased_absolute_neutrophil_counts^^, elevated_uric_acid_levels^^, diarrhea^^, hemorrhoids^^, anorectal_discomfort^^, fatigue^^, elevated_bilirubin^^, taste_disturbance^^, severe_rash^, toxic_epidermal_necrolysis(pm), erythema_multiforme(pm), decreased_total_white_cell_counts^, pre_renal_azotemia(pm), uric_acid_nephropathy(pm)",drugs.com,Drugs@FDA,101224
ondansetron,n/a,mod,antiemetics,"headache^^, drowsiness/sedation^^, wound_problem^^, malaise/fatigue^^, diarrhea^^, constipation^^, eye_disorder^^, dizziness^, paresthesia^, shivers^, fever^, cold_sensation^, xerostomia^, localized_anal/rectal_burning_sensation^, visual_disturbance/transient_visual_disturbances^, sensation_of_warmth/flushing^, bradycardia^, hypotension^, arrhythmias^, cardiopulmonary_arrest(pm), shock(pm), hypoxia^, lower_respiratory_tract_disease^, expectoration^, cough^, shortness_of_breath(pm), laryngeal_edema(pm), stridor(pm), laryngospasm(pm), anxiety/agitation^, disturbance_in_behavior^, sleep_disturbance^, gynecological_disorder^, urinary_retention^, UTI^, rash^, pruritus^, asymptomatic_increases_in_AST/ALT^, liver_failure_and_death(pm_hep_cyto), angioedema(pm)",drugs.com,nzf,101224
quinine,*,mod,antimalarials,"cinchonism",drugs.com,nzf,111224
ribociclib,*,mod,cyclin-dependent_kinase_inhibitors,"alopecia^^, rash^^, pruritus^^, diarrhea^^, constipation^^, abdominal_pain^^, stomatitis^^, dry_mouth^^, dyspepsia^^, UTI^^, decreased_lymphocytes^^, decreased_leukocytes^^, decreased_neutrophils^^, decreased_hemoglobin^^, neutropenia^^, leukopenia^^, decreased_platelets^^, anemia^^, lymphopenia^^, thrombocytopenia^^, increased_ALT^^, increased_AST^^, increased_GGT^^, hepatobiliary_toxicity^^, decreased_blood_glucose^^, decreased_appetite^^, arthralgia^^, back_pain^^, pain_in_extremity^^, headache^^, dizziness^^, increased_lacrimation^^, infections^^, fatigue^^, decreased_phosphorus^^, fever^^, peripheral_edema^^, asthenia^^, hypokalemia^^, decreased_albumin^^, insomnia^^, increased_creatinine^^, cough^^, dyspnea^^, QT_prolongation^, dry_skin^, vitiligo^, erythema^, Stevens_Johnson_syndrome(pm), toxic_epidermal_necrolysis(pm), drug_induced_hypersensitivity_syndrome/drug_reaction_with_eosinophilia_and_systemic_symptoms(pm), febrile_neutropenia^, drug-induced_liver_injury^, increased_blood_bilirubin^, hepatotoxicity^, hypocalcemia^, hypomagnesemia^, hypophosphatemia^, taste_disturbance^, vertigo^, syncope^ dry_eye^, on-treatment_deaths^, oropharyngeal_pain^, COVID-19^, pneumonia^, interstitial_lung disease/pneumonitis^(pm)",drugs.com,nzf,111224
suvorexant,n/a,mod,orexin_receptor_antagonists/hypnotics,"diarrhea^, dry_mouth^, headache^, somnolence^, dizziness^, abnormal_dreams^, cough^, upper_RTI^, palpitations(pm), tachycardia(pm), psychomotor_hyperactivity(pm), anxiety(pm), pruritus(pm)",drugs.com,Drugs@FDA,121224
telithromycin,n/a,mod,ketolides,"diarrhea^^, increased_liver_enzymes^, hepatic_dysfunction(pm), fulminant_hepatitis(pm), hepatic_necrosis(pm), hepatic_failure(pm), severe_hepatitis(pm), gastrointestinal_pain^, flatulence^, pancreatitis(pm), headache^, dizziness^, taste_disturbance, loss_of_consciousness(pm), exacerbation_of_myasthenia_gravis(pm), tremors(pm), convulsions(pm), smell_perversion(pm), ageusia(pm), anosmia(pm), hearing_loss(pm), dyspnea(pm), vaginal_candidiasis^, chromaturia(pm), QT_prolongation(pm), ventricular_arrhythmias(pm), ischemic_cardiac_events(pm), angioneurotic_edema(pm), confusion(pm), visual_hallucinations(pm), arthralgia(pm), myalgia(pm), severe_allergic_reactions(pm), anaphylactic_reactions(pm), hypersensitivity(pm), face_edema(pm)",drugs.com,Drugs@FDA,121224
temsirolimus,n/a,mod,MTOR_inhibitors,"increased_AST^^, bacterial_and_viral_infections^^, dyspnea^^, cough^^, epistaxis^^, pharyngitis^^, pneumonia^^, rhinitis^^, increased_creatinine^^, decreased_hemoglobin^^, decreased_lymphocytes^^, anemia^^, decreased_platelets^^, decreased_leukocytes^^, thrombocytopenia^^, decreased_neutrophils^^, neutropenia^^, chest_pain^^, rash^^, pruritus^^, nail_disorder^^, dry_skin^^, acne^^, asthenia^^, fatigue^^, edema^^, pyrexia^^, pain^^, hyperglycemia^^, mucositis^^, diarrhea^^, abdominal_pain^^, constipation^^, unspecified_urogenital_adverse_reaction^^, UTI^^, increased_total_cholesterol^^, increased_triglycerides^^, increased_ALP^^, hypophosphatemia^^, hypocalcemia^^, decreased_appetite^^, anorexia^^, hyperlipidemia^^, hypokalemia^^, weight_loss^^, hypercholesterolemia^^, hypertriglyceridemia^^, increased_LDH^^, back_pain^^, arthralgia^^, muscle_cramp^^, taste_disturbance^^, headache^^, insomnia^^, increased_total_bilirubin^, increased_ALT^, sepsis^, candidiasis^, fungal_infection^, flu_syndrome^, hypersensitivity_reactions^, upper_RTI^, pleural_effusion^, sinusitis^, interstitial_lung_disease/pneumonitis^, pneumocystis_jiroveci_pneumonia(pm), renal_failure^, leukopenia^, lymphopenia^, hypertension^, venous_thromboembolism^, thrombophlebitis^, pericardial_effusion^, folliculitis^, ecchymosis^, petechiae^, Stevens_Johnson_syndrome(pm), wound_infection/post_operative_wound_infection^, impaired_wound_healing^, angioneurotic_edema_type_reactions(pm), extravasations(pm), diabetes_mellitus^, bowel_perforation^, gastrointestinal_hemorrhage^, rectal_hemorrhage^, gastritis^, dysphagia^, abdominal_distension^, oral_pain^, gingivitis^, oral_thrush^, hemorrhoidal_hemorrhage^, dehydration^, myalgia^, rhabdomyolysis(pm), dizziness^, paresthesia^, somnolence^, convulsion^, complex_regional_pain_syndrome/reflex_sympathetic_dystrophy(pm), conjunctivitis^, depression^, anxiety^",drugs.com,Drugs@FDA,131224