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anatomy_function.ace
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anatomy_function.ace
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Anatomy_function : "WBbtf0001"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001446"
Gene "WBGene00001681"
Involved "WBbt:0005666" Sufficient
Involved "WBbt:0005665" Sufficient
Involved "WBbt:0005661" Sufficient
Remark "NaCl gustatory plasticity defective"
Remark "Published_as gpc-1"
Remark "in gpc-1 mutant, expression of GPC-1 in ADL and ASH neurons resulted in better rescue than expression in ASH neurons alone."
Remark "partial rescue of gpc-1 mutant by ASH-specific expression of GPC-1."
Remark "partial rescue of gpc-1 mutant by ASI-specific expression of GPC-1."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0002"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0001446"
Involved "WBbt:0005666" Necessary
Involved "WBbt:0005665" Necessary
Remark "NaCl gustatory plasticity defective"
Remark "targeted by cell-specific expression of mec-4d/mec-2"
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0003"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000992"
Gene "WBGene00003850"
Involved "WBbt:0005665" Sufficient
Remark "Published_as odr-3"
Remark "avoidance of 1M NaCl"
Remark "expression of ODR-3 in ASH of odr-3 animals fully restored avoidance of 1M NaCl."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0004"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001446"
Gene "WBGene00003850"
Involved "WBbt:0005660" Sufficient
Remark "ADF specific expression of odr-3 restored NaCl avoidance after pre-exposure."
Remark "NaCl gustatory plasticity defective"
Remark "Published_as odr-3"
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0005"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001084"
Gene "WBGene00001709"
Involved "WBbt:0005665" Sufficient
Involved "WBbt:0005661" Sufficient
Remark "Published_as grk-2"
Remark "attractive response to NaCl defective"
Remark "expression of grk-2 by srb-6::grk-2 can restore NaCl chemoattraction in grk-2 mutant."
Remark "expression of grk-2, by srb-6::grk-2 or osm-10::grk-2, can restore NaCl chemoattraction in grk-2 mutant."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0006"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000249"
Gene "WBGene00001709"
Involved "WBbt:0005665" Sufficient
Remark "Published_as grk-2"
Remark "avoidance of 1M glycerol defective"
Remark "specific expression of grk-2 in ASH could restore avoidance of 1M glycerol."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0007"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000412"
Gene "WBGene00001709"
Involved "WBbt:0005665" Sufficient
Remark "0000412"
Remark "Published_as grk-2"
Remark "specific expression of grk-2 in ASH could restore avoidance of octanol."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0008"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0001446"
Involved "WBbt:0003927" Necessary
Involved "WBbt:0004096" Necessary
Involved "WBbt:0006846" Necessary
Remark "NaCl gustatory plasticity defective"
Remark "neuronal activity inhibited by a gcy-32::egl-2(gf) construct."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0009"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001446"
Gene "WBGene00001555"
Involved "WBbt:0003927" Sufficient
Involved "WBbt:0004096" Sufficient
Involved "WBbt:0006846" Sufficient
Remark "NaCl gustatory plasticity defective"
Remark "Published_as gcy-35"
Remark "avoidance after pre-exposure was restored in gcy-32 animals expressing a gcy-32::gcy-35 construct."
Reference "WBPaper00027029"
Anatomy_function : "WBbtf0010"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000184" Autonomous
Gene "WBGene00000417"
Involved "WBbt:0006925" Sufficient
Involved "WBbt:0006925" Necessary
Involved "WBbt:0006925" Remark
Remark "Five obviously mosaic animals are described in categories 1 and 2 of Table 2. The category 1 mosaics are semi-Dpy and Unc. These animals were found to have cell death survivors only among cells generated from the ABp lineage. The category 2 mosaic, with an apparent ABa loss, was semiDpy and non-Unc (although this animal moved more slowly than does a wild-type animal). These results again indicate that ced-3 is cell autonomous and reveal that unc-26, like unc-30, acts in the ABp lineage."
Remark "Genotype \"unc-30(e191) ced-3(n717) dpy-4(e1166); nDp3(IV,V;f)\""
Remark "Published_as ced-3"
Remark "Strain used for ced-3 mosaic analysis"
Remark "ced-3 acts within a dying cell or, possibly, its ancestors."
Reference "WBPaper00001254"
Anatomy_function : "WBbtf0011"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000184" Autonomous
Gene "WBGene00000418"
Involved "WBbt:0006925" Sufficient
Involved "WBbt:0006925" Necessary
Involved "WBbt:0006925" Remark
Remark "Genotype \"ced-4(n1162) dpy-17(e164) unc-36(e251); sDp3(III;f)\""
Remark "Published_as ced-4"
Remark "Strain used for ced-4 mosaic analysis"
Remark "ced-4 acts within a dying cell or, possibly, its ancestors."
Reference "WBPaper00001254"
Anatomy_function : "WBbtf0012"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000443"
Involved "WBbt:0005309" Necessary
Remark "no spicule structure or spicule cuticle material is formed when socket cell is ablated."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0013"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000430"
Involved "WBbt:0005309" Necessary
Remark "male spicule development abnormal."
Remark "no spicule structure or spicule cuticle material is formed when socket cell is ablated."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0014"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001487"
Involved "WBbt:0005309" Necessary
Remark "no spicule structure or spicule cuticle material is formed when socket cell is ablated."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0015"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001487"
Not_involved "WBbt:0005831" Unnecessary
Not_involved "WBbt:0005311" Unnecessary
Remark "elimination of all spicule neurons and sheath cells does not affect spicule morphology."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0016"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000443"
Not_involved "WBbt:0005831" Unnecessary
Not_involved "WBbt:0005311" Unnecessary
Remark "elimination of all spicule neurons and sheath cells does not affect spicule morphology."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0017"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001488"
Involved "WBbt:0004812" Necessary
Remark "ablation of the B.paa cell eliminates the gubernaculum."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0018"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001489"
Involved "WBbt:0004812" Necessary
Remark "ablation of the B.paa cell eliminates the gubernaculum."
Reference "WBPaper00003579"
Anatomy_function : "WBbtf0019"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0001073"
Not_involved "WBbt:0006830" Unnecessary
Remark "Genotype \"egl-1(n986)\""
Remark "egl-1 mutant showed a significantly lower egg-laying rate in the absence of food, similar to that of wild type."
Reference "WBPaper00003951"
Anatomy_function : "WBbtf0020"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000800" Autonomous
Gene "WBGene00003912"
Involved "WBbt:0008588" Necessary
Remark "Genotype \"pal-1(ct224) dpy-17(e164) ncl-1(e1865) unc-36(e251) III; sDp3(III,f); him-8(e1489) IV\""
Remark "Published_as pal-1"
Remark "To identify cells in which pal-1 function is required, we performed a limited mosaic analysis, using two different strains. CF353 carried mutant markers in dpy-17, unc-36, ncl-1, and pal-1(ct224) on LGIII, complemented by wild-type copies on the free duplication sDp3. The losses resulting in posterior phenotypes that we were able to score are summarized in Table 5. Three embryos that appeared to have lost the duplication in either P2 or C [so that the entire C lineage was pal-1(2)] displayed the Nob phenotype."
Remark "posterior development defective, Nob (no back end) phenotype."
Reference "WBPaper00004499"
Anatomy_function : "WBbtf0021"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000254"
Involved "WBbt:0003903" Necessary
Remark "chloride chemotaxis was disrupted by ablation of ASER."
Reference "WBPaper00004609"
Anatomy_function : "WBbtf0022"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001058"
Involved "WBbt:0003903" Necessary
Remark "potassium chemotaxis was disrupted by ablation of ASER."
Reference "WBPaper00004609"
Anatomy_function : "WBbtf0023"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000247"
Involved "WBbt:0003903" Necessary
Involved "WBbt:0003904" Necessary
Remark "Although ablation of ASER had little or no effect on sodium chemotaxis, the effect of bilateral ablation of the ASE neurons was greater than the effect of unilateral ablation of ASEL."
Remark "sodium chemotaxis was disrupted by ablation of ASEL."
Reference "WBPaper00004609"
Anatomy_function : "WBbtf0024"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000265"
Involved "WBbt:0005833" Necessary
Remark "AWC-off ablated animals did not detect 2,3-pentanedione."
Remark "chemotaxis towards 2,3-pentanedione abnormal."
Reference "WBPaper00004610"
Anatomy_function : "WBbtf0025"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000265"
Involved "WBbt:0005833" Necessary
Remark "AWC-off ablated animals did not discriminate benzaldehyde from butanone."
Remark "discrimination of benzaldehyde from butanone abnormal."
Reference "WBPaper00004610"
Anatomy_function : "WBbtf0026"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001503"
Involved "WBbt:0004070" Necessary
Involved "WBbt:0004070" Remark
Remark "30% of animals in which PVT was laser ablated in the L1 stage contained axons that were aberrantly placed across the ventral midline."
Remark "aberrantly placed axons across the midline of ventral nerve cord."
Remark "necessary for L1 stage only."
Reference "WBPaper00005064"
Anatomy_function : "WBbtf0027"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000515" Nonautonomous
Gene "WBGene00006981"
Involved "WBbt:0004070" Sufficient
Involved "WBbt:0005278" Sufficient
Involved "WBbt:0005339" Sufficient
Involved "WBbt:0005304" Sufficient
Remark "ZIG-4 rescuing activity can be disrupted by adding a synthetic transmembrane domain."
Remark "aberrantly placed axons across the ventral midline of ventral nerve cord, including exons of AVK and PVQ but not those of HSN or RMEV."
Remark "expression of ZIG-4 under the control of an unc-4 promoter can rescue the axon defect of PVQ in zig-4 mutants."
Remark "expression of ZIG-4 under the control of its own promoter can rescue the axon defect of PVQ in zig-4 mutants."
Reference "WBPaper00005064"
Anatomy_function : "WBbtf0028"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001084"
Involved "WBbt:0005663" Necessary
Remark "ASE activity is the major determinant of the downstep turn but not of the other (NaCl chemo-attration step) response components."
Reference "WBPaper00025064"
Anatomy_function : "WBbtf0029"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000111"
Involved "WBbt:0006744" Necessary
Remark "ref-1 expression on both the left and right sides of the E16 primordium after killing the precursor of the ligand(LAG-2)-expressing cell for the E4 interaction."
Reference "WBPaper00025235"
Anatomy_function : "WBbtf0030"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001506"
Not_involved "WBbt:0004577" Unnecessary
Not_involved "WBbt:0004574" Unnecessary
Remark "laser ablation of Z1 and Z4 does not affect rate of spontaneous reversal during normal locomotion."
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0031"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001506"
Gene "WBGene00003001"
Not_involved "WBbt:0004577" Unnecessary
Not_involved "WBbt:0004574" Unnecessary
Remark "Z1-Z4-killed lin-12(RNAi) animals maintained high reversal rates comparable to mock treated animals."
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0032"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001506"
Gene "WBGene00003001"
Not_involved "WBbt:0004577" Unnecessary
Not_involved "WBbt:0004574" Unnecessary
Remark "Z1-Z4-killed lin-12p::lin-12(OE) animals maintained high reversal rates comparable to mock treated animals."
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0033"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001506"
Gene "WBGene00003001"
Involved "WBbt:0006836" Necessary
Remark "increased lin-12 activity in the RIG neurons of adult animals increases reversal rates."
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0034"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001506"
Gene "WBGene00003001"
Involved "WBbt:0006836" Necessary
Remark "Genotype \"lin-12(n137n460)\""
Remark "increased lin-12 activity in the RIG neurons of adult animals increases reversal rates."
Remark "lin-12(gfcs)"
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0035"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001506"
Gene "WBGene00003001"
Involved "WBbt:0005842" Sufficient
Involved "WBbt:0005842" Necessary
Involved "WBbt:0005841" Sufficient
Involved "WBbt:0005841" Necessary
Involved "WBbt:0006818" Sufficient
Involved "WBbt:0006818" Necessary
Involved "WBbt:0006819" Sufficient
Involved "WBbt:0006819" Necessary
Involved "WBbt:0005840" Sufficient
Involved "WBbt:0005840" Necessary
Involved "WBbt:0006813" Sufficient
Involved "WBbt:0006813" Necessary
Involved "WBbt:0003850" Sufficient
Involved "WBbt:0003850" Necessary
Involved "WBbt:0006822" Sufficient
Involved "WBbt:0006822" Necessary
Involved "WBbt:0004821" Sufficient
Involved "WBbt:0004821" Necessary
Involved "WBbt:0006976" Sufficient
Involved "WBbt:0006976" Necessary
Involved "WBbt:0006836" Sufficient
Involved "WBbt:0006836" Necessary
Involved "WBbt:0005835" Sufficient
Involved "WBbt:0005835" Necessary
Involved "WBbt:0005045" Sufficient
Involved "WBbt:0005045" Necessary
Involved "WBbt:0005400" Sufficient
Involved "WBbt:0005400" Necessary
Involved "WBbt:0005025" Sufficient
Involved "WBbt:0005025" Necessary
Involved "WBbt:0005023" Sufficient
Involved "WBbt:0005023" Necessary
Involved "WBbt:0005353" Sufficient
Involved "WBbt:0005353" Necessary
Involved "WBbt:0005346" Sufficient
Involved "WBbt:0005346" Necessary
Remark "effects of all the cells were tested together as a whole set, using glr-1 promoter, rather than individually."
Remark "each configuration was used separately to affect lin-12 expression in glr-1-expressing cells"
Remark "rate of spontaneous reversal during normal locomotion (~10 per 3 minutes) abnormal."
Reference "WBPaper00026650"
Anatomy_function : "WBbtf0036"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000117"
Gene "WBGene00000035"
Involved "WBbt:0006804" Necessary
Remark "Genotype \"ace-2 I; ace-3 II; unc-3 daf-6 ace-1 X; mnDp14(X,f)\""
Remark "lack of ace-1(+) in the P1 lineage (which includes 94 of the 95 body muscle cells) is responsible for the Ace-Let phenotype."
Remark "multiple strains were used for mosaic analysis"
Reference "WBPaper00001039"
Anatomy_function : "WBbtf0037"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000646"
Gene "WBGene00000035"
Involved "WBbt:0006804" Necessary
Remark "Ace-Unc"
Remark "Genotype \"ace-2 I; daf-6 ace-1 X; mnDp14(X;f)\""
Remark "loss of ace-1+ at P1 leads to an Ace-Unc phenotype."
Remark "two different genotypes were used separately"
Reference "WBPaper00000761"
Anatomy_function : "WBbtf0038"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000177"
Gene "WBGene00000035"
Involved "WBbt:0006804" Necessary
Remark "Genotype \"ace-2 I; daf-6 ace-1 X; mnDp14(X;f)\""
Remark "acetylcholinesterase activity, histochemically staining, reduced."
Remark "loss of ace-1+ at P1 leads to loss of detectable acetylcholinesterase activity."
Remark "two different genotypes were used separately"
Reference "WBPaper00000761"
Anatomy_function : "WBbtf0039"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001071"
Gene "WBGene00001444"
Not_involved "WBbt:0006830" Insufficient
Remark "Genotype \"flp-1(yn2)\""
Remark "HSN-ablated flp-1 animals were no more severely egg-laying defective than HSN-ablated wild-type animals. In the presence of exogenous serotonin, HSN-ablated flp-1 animals laid eggs significantly more slowly than HSN-ablated wild-type animals."
Reference "WBPaper00003951"
Anatomy_function : "WBbtf0040"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0001073"
Not_involved "WBbt:0006830" Unnecessary
Remark "Genotype \"egl-1(n986)\""
Remark "egl-1 mutant lay eggs significantly less in the absence of food."
Reference "WBPaper00003951"
Anatomy_function : "WBbtf0041"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001070"
Gene "WBGene00001648"
Involved "WBbt:0006830" Necessary
Remark "Genotype \"goa-1(n1134)\""
Remark "The egg-laying inactive phase in HSN-ablated goa-1 mutants was no shorter than in HSN-ablated wild-type animals."
Reference "WBPaper00003951"
Anatomy_function : "WBbtf0042"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000127"
Gene "WBGene00014025"
Involved "WBbt:0006816" Sufficient
Remark "Constitutive asna-1 expression under the control of a sensory neuron-specific promoter from the osm-6 gene promoted dauer exit of daf-7(e1372) mutant animals."
Remark "Genotype \"daf-7(e1372); svEx412[Posm-6:asna-1(++)]\""
Reference "WBPaper00029101"
Anatomy_function : "WBbtf0043"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000229"
Gene "WBGene00014025"
Involved "WBbt:0006816" Sufficient
Remark "Constitutive asna-1 expression under the control of a ciliated sensory neuron-specific promoter from the osm-6 gene rescued the small body size phenotype of asna-1(sv42) mutant animals."
Remark "Genotype \"asna-1(sv42); svEx412[Posm-6::asna-1::gfp]\""
Reference "WBPaper00029101"
Anatomy_function : "WBbtf0044"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000229"
Gene "WBGene00014025"
Involved "WBbt:0005792" Sufficient
Remark "Constitutive asna-1 expression under the control of an intestine-specific promoter from the elt-2 gene rescued the small body size phenotype of asna-1(sv42) mutant animals."
Remark "Genotype \"asna-1(sv42); svEx439[Pelt-2::asna-1::gfp]\""
Reference "WBPaper00029101"
Anatomy_function : "WBbtf0045"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000229" Nonautonomous
Gene "WBGene00014025"
Reference "WBPaper00029101"
Anatomy_function : "WBbtf0046"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001272"
Involved "WBbt:0004522" Necessary
Remark "Genotype \"let-60(n1046); let-341(s1031); gap-1(n1691)\""
Remark "gonad ablation significantly reduces the vulval induction of let-60(gf); let-341(null);gap-1(null) animals."
Reference "WBPaper00004213"
Anatomy_function : "WBbtf0047"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000083" Nonautonomous
Gene "WBGene00000229"
Remark "Genotype \"atp-2(ua2) unc-32(e189) III; svDp1[sDp3[atp-2(+)]-svEx12[unc-4(+)-sur-5::gfp]] Strain WBStrain00047012Reference \""
Remark "Strain name LB146"
Reference "WBPaper00005808"
Anatomy_function : "WBbtf0048"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000061"
Gene "WBGene00000912"
Involved "WBbt:0003679" Sufficient
Involved "WBbt:0005792" Sufficient
Remark "Genotype \"daf-16(mu86); daf-2(e1370)\""
Remark "expressing daf-16 in the intestine (with a ges-1 promoter) increased lifespan by 50%-60%."
Remark "neuronal (unc-119 promoter-driven) daf-16 expression increased lifespan 5%-20%, up to that of wild-type."
Reference "WBPaper00006226"
Anatomy_function : "WBbtf0049"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000013"
Gene "WBGene00000912"
Involved "WBbt:0003679" Sufficient
Involved "WBbt:0005792" Sufficient
Remark "Genotype \"daf-16(mu86); daf-2(e1370)\""
Remark "expressing daf-16::gfp in the intestine (with a ges-1 promoter) had a small effect on dauer formation."
Remark "neuronal (unc-119 promoter-driven) daf-16 expression was sufficient to promote dauer formation in daf-16(mu86); daf-2(e1370) mutants."
Reference "WBPaper00006226"
Anatomy_function : "WBbtf0050"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000013" Nonautonomous
Gene "WBGene00000912"
Involved "WBbt:0004015" Sufficient
Involved "WBbt:0006874" Sufficient
Remark "AB-mosaics were able to become dauers."
Remark "Genotype \"daf-16(mu86); daf-2(e1370) ncl-1(e1865); muEx258\""
Remark "P1-mosaics were able to become dauers."
Remark "actual experimental temperature is 25.5 degrees"
Reference "WBPaper00006226"
Anatomy_function : "WBbtf0051"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000039" Nonautonomous
Gene "WBGene00000912"
Involved "WBbt:0006874" Sufficient
Involved "WBbt:0004015" Sufficient
Remark "AB-mosaics had extended lifespans."
Remark "Genotype \"daf-16(mu86); daf-2(e1370) ncl-1(e1865); muEx258\""
Remark "P1-mosaics had extended lifespans."
Remark "Strain name CF1803"
Reference "WBPaper00006226"
Anatomy_function : "WBbtf0052"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000061"
Gene "WBGene00000912"
Involved "WBbt:0005792" Sufficient
Remark "Genotype \"daf-16(mu86); mes-1(bn7)\""
Remark "expressing daf-16 in the intestine (with a ges-1 promoter) completely restored the longevity of daf-16(-); mes-1(bn7) germline-less animals."
Reference "WBPaper00006226"
Anatomy_function : "WBbtf0053"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000245"
Involved "WBbt:0006780" Sufficient
Involved "WBbt:0006781" Sufficient
Involved "WBbt:0004522" Sufficient
Involved "WBbt:0007809" Sufficient
Remark "Anchor cell, ventral and dorsal uterine precursor cells and the induced VPC cells appear to all be sources of attraction and repulsion to sex myoblast migration."
Reference "WBPaper00004362"
Anatomy_function : "WBbtf0054"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0001272" Autonomous
Gene "WBGene00000238"
Involved "WBbt:0008117" Necessary
Remark "Analysed 13 mosaic animals in which P4.p lacked the extrachromosomal array and found that this cell adopted the F (mutant) fate in 11 cases."
Remark "ENTITY:WBbt:0006892(P4.p)|GO:0001708(cell fate specification) QUALITY:PATO:0001507(disrupted)"
Remark "Genotype \"unc-29(e1072); ncl-1(e1942); unc-30(e191); bar-1(ga80); gaEx117[F35D3; C33C3; pSC11; pDE204]\""
Remark "Published_as bar-1"
Reference "WBPaper00003200"
Anatomy_function : "WBbtf0055"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0001507"
Gene "WBGene00000270"
Involved "WBbt:0005792" Necessary
Remark "among progeny of transgenic animals, all mosaic, toxin-resistant animals have lost extra-chromosomal array carrying bre-5(+) in the gut lineage."
Reference "WBPaper00004776"
Anatomy_function : "WBbtf0056"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000717"
Involved "WBbt:0005175" Necessary
Remark "ceh-14::lacZ (pLZ14-2 reporter) expression in hypodermis was affected."
Remark "no hypodermal expression of ceh-14::lacZ is seen in animals underwent laser ablation of Z1, Z2, Z3, Z4 gonadal precursors."
Reference "WBPaper00004435"
Anatomy_function : "WBbtf0057"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000232" Autonomous
Gene "WBGene00000289"
Involved "WBbt:0006827"
Remark "Genotype \"cam-1(gm122); ncl-1(e1865); kyls5[ceh-23-unc-76-gfp; lin-15];gmEx188[pCAM-1; ncl-1(+); pRF4rol-6(dm)]\""
Reference "WBPaper00003653"
Anatomy_function : "WBbtf0058"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000220"
Involved "WBbt:0004522" Necessary
Remark "ablation of AC at the late P6.px to early P6.pxx stage (but not at the late P6.pxx stage) affects zmp-1::GFP expression in P6.pxxx during L4 lethargus."
Remark "vulval primary lineage patterning (P6.pxx, vulE vs. vulF fates) defective."
Reference "WBPaper00004481"
Anatomy_function : "WBbtf0059"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000885"
Gene "WBGene00000420"
Involved "WBbt:0007803" Remark
Remark "Genotype \"dpy-17(e164) ced-6(n1813) mec-14(u55) ncl-1(e1865) unc-36(e251)III; sDp3\""
Remark "mosaic analysis demonstrates that ced-6 acts within the engulfing gonadal sheath cells rather than the germline apoptotic cells."
Reference "WBPaper00003090"
Anatomy_function : "WBbtf0060"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000707"
Involved "WBbt:0005793"
Remark "specific defect: anterior pharyngeal extension abnormal."
Reference "WBPaper00004707"
Anatomy_function : "WBbtf0061"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000885"
Gene "WBGene00000421"
Involved "WBbt:0006925" Necessary
Involved "WBbt:0007803" Necessary
Remark "Genotype \"ncl-1(e1865) unc-36(e251) ced-7(n1892); qDp3(ncl-1(+) unc-36(+) ced-7(+))\""
Remark "mosaic animals that lost qDp3 in sheath cells of the gonad arms showed the Ced-7 phenotype."
Remark "mosaic animals that lost qDp3 in the germline showed the Ced-7 phenotype."
Remark "strain name MT9149"
Reference "WBPaper00003091"
Anatomy_function : "WBbtf0062"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0004026"
Gene "WBGene00001172"
Involved "WBbt:0007804" Sufficient
Remark "Genotype \"glr-1(n2461);egl-3(nu349)\""
Remark "expression of egl-3 in the command neurons (using the glr-1 promoter) rescued the glr-1 (nose touch defective) suppression defect."
Remark "glr-1 single mutants are nose-touch insensitive, whereas glr-1;egl-3 double mutants are nose-touch sensitive."
Reference "WBPaper00004977"
Anatomy_function : "WBbtf0063"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0000643"
Involved "WBbt:0006830" Necessary
Remark "Genotype \"egl-1(n986)\""
Remark "egl-1 mutant animals (lack HSN neurons) did not display the velocity peak prior to egg-laying, nor did they exhibit the reversal frequency peak after egg-laying."
Remark "specific defect: execution of the egg-laying motor program correlates with two changes in locomotive behavior: an increased propensity for forward locomotion before egg-laying, and an increased propensity for directional changes, in particular reversals, during and after an egg-laying event."
Reference "WBPaper00004978"
Anatomy_function : "WBbtf0064"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000643"
Involved "WBbt:0003851" Necessary
Remark "in AVF-ablated animals, the velocity burst prior to egg-laying was reduced if not eliminated, and the average velocity overall was significantly reduced; in addition, the peak in directional change probability after egg-laying was eliminated."
Remark "specific defect: execution of the egg-laying motor program correlates with two changes in locomotive behavior: an increased propensity for forward locomotion before egg-laying, and an increased propensity for directional changes, in particular reversals, during and after an egg-laying event."
Reference "WBPaper00004978"
Anatomy_function : "WBbtf0065"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0000643"
Not_involved "WBbt:0005842" Unnecessary
Not_involved "WBbt:0005840" Unnecessary
Remark "Genotype \"akIs11\""
Remark "akIs11 uses the nmr-1 promoter to express ICE protease, which induces cell death, in a subset of command interneurons."
Remark "nmr-1::ICE strain exhibited a significant velocity burst prior to egg-laying."
Remark "specific defect: execution of the egg-laying motor program correlates with two changes in locomotive behavior: an increased propensity for forward locomotion before egg-laying, and an increased propensity for directional changes, in particular reversals, during and after an egg-laying event."
Reference "WBPaper00004978"
Anatomy_function : "WBbtf0066"
Assay "Genetic_ablation"
Phenotype "WBPhenotype:0000643"
Not_involved "WBbt:0005842" Unnecessary
Not_involved "WBbt:0005840" Unnecessary
Not_involved "WBbt:0005841" Unnecessary
Not_involved "WBbt:0006822" Unnecessary
Remark "Genotype \"kyIs36\""
Remark "glr-1::ICE strain exhibited a significant velocity burst prior to egg-laying."
Remark "kyIs36 uses the glr-1 promoter to express ICE protease, which induces cell death, in a subset of command interneurons."
Remark "specific defect: execution of the egg-laying motor program correlates with two changes in locomotive behavior: an increased propensity for forward locomotion before egg-laying, and an increased propensity for directional changes, in particular reversals, during and after an egg-laying event."
Reference "WBPaper00004978"
Anatomy_function : "WBbtf0067"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000529" Autonomous
Gene "WBGene00000439"
Involved "WBbt:0005753" Sufficient
Involved "WBbt:0005753" Necessary
Remark "specific phenotype: embryonic seam cell development abnormal."
Reference "WBPaper00024903"
Anatomy_function : "WBbtf0068"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0000471" Nonautonomous
Gene "WBGene00000478"
Not_involved "WBbt:0005406" Insufficient
Not_involved "WBbt:0005406" Unnecessary
Remark "to generate transgenic animals, a PCR fragment containing all of the predicted cfz-2 coding region plus 4.7 kb of upstream sequence from wild type was coinjected with pTG96 (plasmid carrying a sur-5::gfp transgene) into cfz-2(cw49) homozygous mutants."
Reference "WBPaper00026706"
Anatomy_function : "WBbtf0069"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004007"
Involved "WBbt:0007806" Necessary
Involved "WBbt:0006859" Necessary
Involved "WBbt:0006930" Necessary
Remark "removal of both the hook sensillum and the postcloacal sensilla neurons PCA and PCB resulted in males that showed no spicule activity."
Reference "WBPaper00005027"
Anatomy_function : "WBbtf0070"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000279"
Involved "WBbt:0004968" Necessary
Involved "WBbt:0004967" Necessary
Not_involved "WBbt:0006862" Unnecessary
Not_involved "WBbt:0007805" Unnecessary
Remark "although each SPC neuron is associated with a separate spicule, either cell facilitates insertion of both copulatory structures."
Reference "WBPaper00005027"
Anatomy_function : "WBbtf0071"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004008"
Involved "WBbt:0006794" Necessary
Remark "somatic cells of the gonad can lengthen the duration of protractor contraction; maximal duration of protractor contraction requires proper connection of the gonad to the cloaca."
Reference "WBPaper00005027"
Anatomy_function : "WBbtf0072"
Assay "Genetic_mosaic"
Phenotype "WBPhenotype:0004008"
Gene "WBGene00001187"
Involved "WBbt:0005826" Necessary
Remark "EGL-19 in the protractors promotes prolonged contractions."
Remark "Genotype \"egl-19(st556); him-5; syEx515\""
Reference "WBPaper00005027"
Anatomy_function : "WBbtf0073"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004004"
Involved "WBbt:0006942" Necessary
Involved "WBbt:0006950" Necessary
Involved "WBbt:0006952" Necessary
Remark "males with dorsally opening (of sensory openings) rays ablated failed to respond to dorsal contact with the hermaphrodite."
Remark "specific phenotype: male response to dorsal tail contact of hermaphrodite abnormal."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0074"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004004"
Involved "WBbt:0006945" Necessary
Involved "WBbt:0006949" Necessary
Involved "WBbt:0006953" Necessary
Involved "WBbt:0006930" Necessary
Involved "WBbt:0005487" Necessary
Involved "WBbt:0005312" Necessary
Remark "males lacking ventral sensory organs and the ventrally opening rays do not respond to ventral contact with the hermaphrodite."
Remark "males lacking ventral sensory organs and the ventrally opening rays do not respond to ventral contact with the hermaphrodite."
Remark "specific phenotype: male response to ventral tail contact of hermaphrodite abnormal."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0075"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000227"
Involved "WBbt:0006952" Necessary
Involved "WBbt:0006953" Necessary
Involved "WBbt:0006954" Necessary
Remark "TL/R.ap ablated (missing rays 7-9) males swim past the end of the hermaphrodite, losing contact and ending with their tail in a tight ventral coil."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0076"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004004"
Involved "WBbt:0006942" Necessary
Involved "WBbt:0006945" Necessary
Involved "WBbt:0006948" Necessary
Involved "WBbt:0006949" Necessary
Involved "WBbt:0006950" Necessary
Involved "WBbt:0006951" Necessary
Remark "ablation of V5L/R.p and V6L/R.p results in males missing rays 1-6; these males are incapable of responding to contact with hermaphrodites."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0077"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000227"
Involved "WBbt:0006856" Necessary
Involved "WBbt:0006857" Necessary
Involved "WBbt:0006858" Necessary
Remark "ablation of R(5/7/9).a neurons results in males that turn at the of the hermaphrodite but tend to do so in a large, sloppy arc instead of the tight ventral coil seen in intact animals."
Remark "specific phenotype: males that turn at the of the hermaphrodite but tend to do so in a large, sloppy arc instead of the tight ventral coil seen in intact animals."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0078"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004009"
Involved "WBbt:0006930" Necessary
Remark "operated males fail to stop at the vulva, circling the hermaphrodite many times."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0079"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0004010"
Involved "WBbt:0005487" Necessary
Remark "operated animals respond, turn, and readily stop in the general area of the vulva but they tend to lose the vulva while attempting to locate its precise position."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0080"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000284"
Involved "WBbt:0006862" Necessary
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0081"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0000279"
Involved "WBbt:0006861" Necessary
Involved "WBbt:0007805" Necessary
Remark "ablation of either the SPC motoneurons or the SPD sensory neurons resulted in males defective in spicule insertion."
Reference "WBPaper00002109"
Anatomy_function : "WBbtf0082"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001450"
Involved "WBbt:0005665" Necessary
Involved "WBbt:0005668" Necessary
Remark "animals in which the ASH neurons were ablated showed reduced response to SDS; animals in which the ASH and the ASK neurons had both been ablated showed a response to SDS that was significantly lower than that of animals in which only the ASH neurons had been ablated."
Remark "specific phenotype: SDS avoidance"
Reference "WBPaper00005242"
Anatomy_function : "WBbtf0083"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001450"
Involved "WBbt:0005665" Necessary
Involved "WBbt:0005668" Necessary
Remark "animals in which the ASH neurons were ablated showed reduced response to SDS; animals in which the ASH and the ASK neurons had both been ablated showed a response to SDS that was significantly lower than that of animals in which only the ASH neurons had been ablated."
Remark "specific phenotype: SDS avoidance defect"
Reference "WBPaper00005242"
Anatomy_function : "WBbtf0084"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001450"
Involved "WBbt:0007807" Necessary
Involved "WBbt:0007808" Necessary
Remark "ablation of PHA and PHB did not result in an avoidance defect; however, animals in which ASH, PHA, and PHB were killed showed a significantly stronger avoidance response to SDS than animals in which ASH alone was killed."
Remark "specific phenotype: SDS avoidance defect"
Reference "WBPaper00005242"
Anatomy_function : "WBbtf0085"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001291"
Gene "WBGene00003839"
Involved "WBbt:0005665" Sufficient
Involved "WBbt:0005661" Sufficient
Remark "Genotype \"ocr-2(ak47) IV; npr-1(ad609) lin-15(n765ts)\""
Remark "expression of ocr-2 in the ASH or ADL neurons restores aggregation behavior to ocr-2; npr-1 mutant animals."
Remark "strain name CX4827"
Reference "WBPaper00005511"
Anatomy_function : "WBbtf0086"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001291"
Gene "WBGene00003851"
Involved "WBbt:0005661" Sufficient
Remark "Genotype \"odr-4(n2144) III; npr-1(ad609) lin-15(n765ts) X\""
Remark "odr-4 expression in ADL restores social behavior to odr-4; npr-1 mutant animals."
Remark "strain name AX215"
Reference "WBPaper00005511"
Anatomy_function : "WBbtf0087"
Assay "Laser_ablation"
Phenotype "WBPhenotype:0001291"
Involved "WBbt:0005661" Necessary
Involved "WBbt:0005665" Necessary
Remark "ablatin of both pairs of ADL and ASH neurons suppresses aggregation; ablation of the ASH neuron pair, the ADL neuron pair, or the ASH neuron pair and 1 ADL neuron, does not suppress aggregation."
Reference "WBPaper00005511"
Anatomy_function : "WBbtf0088"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0001472"
Gene "WBGene00002335"
Involved "WBbt:0005672" Sufficient
Remark "Genotype \"let-60(n2021)\""
Remark "gcy-10::let-60(gf) transgenic line showed a chemotaxis defect towards isoamylalcohol; gcy-10::let-60(+) restored the response of let-60(lf) mutants to isoamylalcohol. gcy-10 promoter is active in AWC, AWB, and I1."
Reference "WBPaper00003955"
Anatomy_function : "WBbtf0089"
Assay "Blastomere_isolation"
Phenotype "WBPhenotype:0000080"
Gene "WBGene00000148"
Involved "WBbt:0004458" Sufficient
Involved "WBbt:0005865" Sufficient
Involved "WBbt:0006162" Sufficient
Remark "AB blastomeres were isolated from hermaphrodites from the strain PD8260 (ceh-22::lacZ) or unc-29 hermaphrodites from the strain JJ977 [unc-29(e1072) aph-2(zu181)/hT2; ceh-22::lacZ]. The P1 blastomeres were isolated from N2 hermaphrodites or unc-29 hermaphrodites from the strain JJ1077 [unc-29(e1072) aph-2(zu181)/hT2]"
Remark "aph-2(+) function apparently can be supplied by either the signaling cell (MS), or by the responding cells (AB descendants)."
Reference "WBPaper00004188"
Anatomy_function : "WBbtf0090"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000384" Autonomous
Gene "WBGene00003143"
Involved "WBbt:0005270" Sufficient
Involved "WBbt:0005303" Sufficient
Remark "specific expression of MAX-1 the DD and VD neurons using the unc-25 promoter fully rescued the axon guidance defects of DD and VD neurons in max-1 mutants."
Reference "WBPaper00005251"
Anatomy_function : "WBbtf0091"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000699" Autonomous
Phenotype "WBPhenotype:0000699" Nonautonomous
Gene "WBGene00000393"
Involved "WBbt:0007809" Sufficient
Involved "WBbt:0005792" Sufficient
Remark "CDF-1 expression in the Pn.p cells (under the control of lin-31 promoter) is sufficient to rescue the mutant phenotype."
Remark "CDF-1 expression in the intestinal cells (under the control of ges-1 promoter) can partially rescue the defects in vulval development."
Remark "Genotype \"let-60(n1046gf); cdf-1(n2527)\""
Reference "WBPaper00005255"
Anatomy_function : "WBbtf0092"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000047"
Gene "WBGene00004215"
Involved "WBbt:0003679" Sufficient
Remark "Genotype \"vab-1(e2) ptp-3(op147)\""
Remark "expression of PTP-3 under the control of the pan-neural unc-119 promoter caused a significant decrease in teh lethality of vab-1 ptp-3 double mutants."
Reference "WBPaper00005259"
Anatomy_function : "WBbtf0093"
Assay "Expression_mosaic"
Phenotype "WBPhenotype:0000525" Nonautonomous
Gene "WBGene00001841"
Involved "WBbt:0005663" Sufficient
Remark "Genotype \"hen-1(tm501)\""