Question Regarding Estimating Ligand-Target Matrix Using Custom GR Network

[peipp410]

Hi there,

I have used my own method to estimate the regulatory strength of a gene regulatory network, and the results are stored in an n_
tf × n_hvg matrix (gr_network). I would like to know if it's possible to download the existing ligand_tf_matrix_nsga2r_final.rds and then multiply it by my own gr_network matrix (by selecting matching gene features) to obtain the final ligand_target_matrix.

Is this approach valid? Thank you for your help!