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From Thuillier L. Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase. Biochim Biophys Acta. 1978;524(1):198-206. doi:10.1016/0005-2744(78)90118-3:
Biosynthetic reactions which produce pyrophosphate (polysaccharides, proteins, DNA and RNA synthesis} are subject to a "thermodynamic pull" [1--3] due to the subsequent complete and irreversible hydrolysis of pyrophosphate by widely distributed pyrophosphatases (standard free energy of hydrolysis: AG ° = --23.56 kJ • mo1-1 of PPi in the absence of divalent cations[4]).
The following enzyme catalyzed reactions would be considered to be reversible:
Orotate phosphoribosyltransferase, catalyzed by UMPS
Nicotinamide phosphoribosyltransferase, catalyzed by NAMPT
Hypoxanthine phosphoribosyltransferase, catalyzed by HPRT1
Current status:
Identifier
Reaction equation
Genes
ORPT
orot5p_c + ppi_c <=> orot_c + prpp_c
UMPS
NMNS
h_c + ncam_c + prpp_c --> nmn_c + ppi_c
NAMPT
HXPRT
hxan_c + prpp_c --> imp_c + ppi_c
HPRT1
Proposed status/to-do list:
Identifier
Reaction equation
Genes
ORPT
orot_c + prpp_c <=> orot5p_c + ppi_c
UMPS
NMNS
h_c + ncam_c + prpp_c <=> nmn_c + ppi_c
NAMPT
HXPRT
hxan_c + prpp_c <=> imp_c + ppi_c
HPRT1
Reverse stoichiometry for ORPT.
Set NMNS as reversible.
Set HXPRT as reversible.
The text was updated successfully, but these errors were encountered:
Brief description:
From Thuillier L. Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase. Biochim Biophys Acta. 1978;524(1):198-206. doi:10.1016/0005-2744(78)90118-3:
Biosynthetic reactions which produce pyrophosphate (polysaccharides, proteins, DNA and RNA synthesis} are subject to a "thermodynamic pull" [1--3] due to the subsequent complete and irreversible hydrolysis of pyrophosphate by widely distributed pyrophosphatases (standard free energy of hydrolysis: AG ° = --23.56 kJ • mo1-1 of PPi in the absence of divalent cations[4]).
The following enzyme catalyzed reactions would be considered to be reversible:
Current status:
Proposed status/to-do list:
The text was updated successfully, but these errors were encountered: