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[User Story] Update TIDDIT to make use of single-end reads #1467

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mathiasbio opened this issue Jul 25, 2024 · 1 comment · May be fixed by #1470
Open
3 tasks

[User Story] Update TIDDIT to make use of single-end reads #1467

mathiasbio opened this issue Jul 25, 2024 · 1 comment · May be fixed by #1470
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User-Story A User-Story describing new functionality
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@mathiasbio
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Need

As a clinician I want to detect as many true SVs as possible. After the update planned in balsamic 16.0.0 we're going to have a lot more single-end reads in our bam files due to the UMI collapse implemented here: #1358

In a a recent version of TIDDIT there has been an update that greatly improves the use of single end reads in SV variant calling: https://github.com/SciLifeLab/TIDDIT/releases

It seems then like an opportune time to update TIDDIT as a part of release 16.

Suggested approach

Update TIDDIT and implement in release 16.

Test the new version in the new deduplicate with UMIs branch: #1358

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  • Yes, I have reviewed the system requirements

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Risk assessment needed

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@mathiasbio mathiasbio added the User-Story A User-Story describing new functionality label Jul 25, 2024
@mathiasbio mathiasbio assigned mathiasbio and unassigned mathiasbio Jul 25, 2024
@mathiasbio mathiasbio added this to the Release 16 milestone Jul 25, 2024
@ivadym
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ivadym commented Aug 14, 2024

I opened an issue for the package to be uploaded to Bioconda: SciLifeLab/TIDDIT#119.

I reviewed the errors and it seems there's a bug in the TIDDIT code. However, I'm not very familiar with Bioconda recipes. I also encountered a similar error with Cython when attempting to install it from scratch.

@ivadym ivadym linked a pull request Aug 14, 2024 that will close this issue
54 tasks
@jemten jemten modified the milestones: Release 16, Release 17 Sep 2, 2024
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3 participants