Alk ligands Augα regulate metabolism through hypothalamic control of body weight independent from Mc4r in the PVN Hypothalamus

This repository enables reproducible analysis characterizing the role of ALK/ MC4R signalling in hypothalamic control of metabolism based on single-cell RNA-seq data from the paraventricular nucleus of the hypothalamus for the article: Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. A hypothalamic pathway for Augmentor α-controlled body weight regulation. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2200476119. doi: 10.1073/pnas.2200476119. Epub 2022 Apr 11. Erratum in: Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2209128119. PMID: 35412887; PMCID: PMC9169862.