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Simplified version of a deterministic framework for modeling whole chromosome missegregations. This model is more amendable to theoretical analysis to investigate conditions for missegregation-induced extinction (MIE).
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MathOnco/MIEmodel
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.Rmd files in /Rscripts can be run to generate the figures and data in their respective files. Note that all the .Rmd files expect the root dir to be set to the path currently inhabited by this readme, and /figures and /data should exist inside this path. Info on R/package versions: > sessionInfo() R version 4.1.0 (2021-05-18) Platform: x86_64-w64-mingw32/x64 (64-bit) Running under: Windows 10 x64 (build 17763) Matrix products: default locale: [1] LC_COLLATE=English_United States.1252 LC_CTYPE=English_United States.1252 [3] LC_MONETARY=English_United States.1252 LC_NUMERIC=C [5] LC_TIME=English_United States.1252 attached base packages: [1] parallel stats graphics grDevices utils datasets methods base other attached packages: [1] gganimate_1.0.7 egg_0.4.5 gridExtra_2.3 stringr_1.4.0 ggpubr_0.4.0 [6] R.utils_2.10.1 R.oo_1.24.0 R.methodsS3_1.8.1 pbapply_1.5-0 deSolve_1.29 [11] ggplot2_3.3.5 loaded via a namespace (and not attached): [1] progress_1.2.2 tidyselect_1.1.1 xfun_0.25 reshape2_1.4.4 purrr_0.3.4 [6] carData_3.0-4 colorspace_2.0-2 vctrs_0.3.8 generics_0.1.0 viridisLite_0.4.0 [11] htmltools_0.5.2 yaml_2.2.1 utf8_1.2.2 rlang_0.4.11 pillar_1.6.2 [16] glue_1.4.2 withr_2.4.2 DBI_1.1.1 tweenr_1.0.2 lifecycle_1.0.0 [21] plyr_1.8.6 munsell_0.5.0 ggsignif_0.6.3 gtable_0.3.0 evaluate_0.14 [26] labeling_0.4.2 knitr_1.33 fastmap_1.1.0 gifski_1.4.3-1 fansi_0.5.0 [31] broom_0.7.9 Rcpp_1.0.7 backports_1.2.1 scales_1.1.1 abind_1.4-5 [36] farver_2.1.0 hms_1.1.0 digest_0.6.27 stringi_1.7.3 rstatix_0.7.0 [41] dplyr_1.0.7 grid_4.1.0 cowplot_1.1.1 tools_4.1.0 magrittr_2.0.1 [46] tibble_3.1.3 car_3.0-12 tidyr_1.1.3 crayon_1.4.1 pkgconfig_2.0.3 [51] ellipsis_0.3.2 prettyunits_1.1.1 assertthat_0.2.1 rmarkdown_2.10 R6_2.5.0 [56] compiler_4.1.0
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Simplified version of a deterministic framework for modeling whole chromosome missegregations. This model is more amendable to theoretical analysis to investigate conditions for missegregation-induced extinction (MIE).
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