SUMMARY.md

Table of contents

• README
• Open Systems Pharmacology Suite Manual & Copyright
• How to Contribute

Mechanistic Modeling of Pharmacokinetics and Dynamics

• Best Practices

  • Introduction
  • Model Development
  • Model Evaluation
  • Application Simulation
  • Documentation

• Modeling Concepts

  • PBPK Modeling - Systems Biology
  • PK and PD Modeling
  • Principles of PBPK Modeling
  • Expression Data for PBPK Modeling
  • Modeling of Proteins
  • PD and Reaction Network Modeling

Open Systems Pharmacology Suite

• Modules, Philosophy, and Building Blocks
• Getting Started

Working with PK-Sim

• PK-Sim Documentation
  • Quick Guide‌
  • Options
  • Projects
  • Creating Individuals
  • Creating Populations
  • Expression Profile
  • Compounds: Definition and Work Flows
  • Compounds: Defining Inhibition/Induction Processes
  • Administration Protocols
  • Events
  • Formulations
  • Simulations
  • Importing and Exporting Project Data and Models
  • Conversion of Projects from Previous Version
  • Command Line Interface - CLI

Working with MoBi

• MoBi‌ Documentation
  • First Steps
  • The Building Block Concept
  • Model Building and Model Components
  • Setting up a Simulation
  • Simulation Results
  • Diagrams Overview
  • Tools
  • Reuse of Project Information from Previous Versions

Shared Tools and Example Workflows

• Features of Tables
• Chart Component
• Comparison of Building Blocks
• Parameter Identification
• Sensitivity Analysis
• Import and Edit of Observed Data
• Default, Display and Base Units
• Working Journal
• History Manager and History Reporting‌
• Setting up a Reaction Network‌
• Setting up a Drug-Drug Interaction in PK-Sim‌
• Qualification‌

Working with R‌

• ospsuite-R Documentation
• Reporting Engine (RE)
• TLF Library

Appendix

• Appendix
• OSP Suite Fact Sheet

References

• References