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feat: first version in the new repository
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clintval committed Jul 26, 2024
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Expand Up @@ -11,22 +11,12 @@ Disambiguate reads that were mapped to multiple references.

![Torres del Paine](.github/img/cover.jpg)

#### Installation

Install with the Conda or Mamba package manager after setting your [Bioconda channels](https://bioconda.github.io/user/install.html#set-up-channels):

```text
❯ conda install neodisambiguate
```

#### Features

- Accepts SAM/BAM sources of any sort order
- Will disambiguate an arbitrary number of BAMs, all aligned to different references
- Writes the ambiguous alignments to a separate directory
- Extensible implementation which supports alternative disambiguation strategies
- Benchmarks show high accuracy: [Click Here](benchmarks/disambiguate.md)

#### Introduction

Disambiguation of aligned reads is performed per-template and all information across primary, secondary, and supplementary alignments is used as evidence.
Expand All @@ -41,6 +31,14 @@ Input BAMs of arbitrary sort order are accepted, however, an internal sort to qu
All output BAM files will be written in the same sort order as the input BAM files.
Although paired-end reads will give the most discriminatory power for disambiguation of short-read sequencing data, this tool accepts paired, single-end (fragment), and mixed pairing input data.

#### Features

- Accepts SAM/BAM sources of any sort order
- Will disambiguate an arbitrary number of BAMs, all aligned to different references
- Writes the ambiguous alignments to a separate directory
- Extensible implementation which supports alternative disambiguation strategies
- Benchmarks show high accuracy: [Click Here](benchmarks/disambiguate.md)

#### Command Line Usage

```bash
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