AHoJ & AHoJ-DB: Apo-Holo Protein Search

Webserver & command-line tool for search of Apo (unbound) protein structures from Holo (bound) forms and vice versa.

Features

• customizable search of Apo-Holo pairs in the PDB
• alignment to the query structure
• batch mode for fast parallel dataset processing
• visualization via Molstar and PyMol
• public documented REST-API

Web version

Web interface is now available at: https://apoholo.cz

Standalone version

Standalone Python command line application: https://github.com/ioChris/AHoJ

AHoJ-DB database

https://apoholo.cz/db

AHoJ-DB is a database of pre-computed AHoJ searches for almost all proteins and ligands in the PDB.

Publications

Papers

If you find AHoJ or AHoJ-DB useful, please cite relevant papers.

AHoJ: Article

AHoJ-DB: Article

Poster

Poster introducing the method: https://www.researchgate.net/publication/359512815_AHoJ_Rapid_tailored_search_and_retrieval_of_apo_and_holo_protein_structures

Future updates

The project will be released soon as open source on GitHub. ⭐ or follow this repo for further updates.