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2010 Ph.D. Botstein Lab, Princeton University
2004 B.S. Massachusetts Institute of Technology |
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My laboratory aims to understand the rules governing emergent systems-level behavior and to use these rules to rationally engineer biological systems. We make quantitative measurements, often at the single-cell level, to test different conceptual frameworks and discriminate among different classes of models. Areas of focus include:
- Translational control of protein synthesis: Mechanisms by which ribosomal modifications regulate protein synthesis
- Single-cell protein analysis: We develop and apply mass-spectrometry methods that allow analyzing thousands of proteins in single cells. These data have enabled characterizing post-transcriptional regulation in single cells at systems level, as well as discovering macrophage polarization in the absence of polarizing cytokines.
I received a BS from MIT in 2004 and then pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. As a postdoc in the van Oudenaarden laboratory at MIT, I characterized trade-offs of aerobic glycolysis (also known as Warburg effect) and obtained direct evidence for differential stoichiometry among core ribosomal proteins, suggesting that specialized ribosomes regulate protein synthesis.