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Question regarding ligand prioritization #312

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kaizen89 opened this issue Dec 18, 2024 · 0 comments
Open

Question regarding ligand prioritization #312

kaizen89 opened this issue Dec 18, 2024 · 0 comments

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@kaizen89
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Hi all,
I tried the recommended method to order by aupr_corrected
image

Second method

best_upstream_ligands %>% lapply(get_weighted_ligand_target_links,geneset = geneset_oi, ligand_target_matrix = ligand_target_matrix, n = 200) %>% bind_rows() %>% drop_na() >% group_by(ligand) %>% summarise(sum(weight)) %>% arrange(desc(`sum(weight)`)) %>% pull(ligand)

image

Which one makes more sense in this case?
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@kaizen89