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3023884

amolin19 edited this page May 4, 2021 · 2 revisions

3023884 - Cholesterol in HDL/Cholesterol.total [Mass Ratio] in Serum or Plasma

Cholesterol is a fatty substance your liver makes. It’s also found in certain foods. Your body needs some cholesterol to function properly. Your total cholesterol level is the overall amount of cholesterol found in your blood. It consists of: low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triglycerides. LDL is also called "bad" cholesterol because it blocks your blood vessels and increases your risk for heart disease. HDL is considered "good" cholesterol because it helps protect you from heart disease. The higher your HDL, the better. Finally, total cholesterol includes a triglycerides count. These are another type of fat that can build up in the body and are considered the "building blocks" of cholesterol. 1

The test Cholesterol in HDL/Cholesterol.total [Mass Ratio] in Serum or Plasma reports the ratio of HDL cholesterol to total cholesterol in the blood. This test should not be confused with the inverse ratio, total cholesterol / HDL cholesterol, which is commonly referred to as the "cholesterol ratio".

In the OMOP vocabulary 3023884 is a Standard Concept that represents the measurement Cholesterol in HDL/Cholesterol.total [Mass Ratio] in Serum or Plasma

The recommended low and high values for each unit associated with 3023884 are below. These are not meant to be normal values. Rather, these are meant to be biologically plausible values. For example, it would be implausible to see a patient with a weight of 0 kg though a person could be 2.5 kg.

In the OMOP vocabulary 8554 is a Standard Concept that represents the unit PERCENT

Plausible Low Value

1.0

Plausible High Value

100.0

Rationale

The range 1-100 was chosen based on values seen in real world data. The following study 2 discusses the potential for an LDL level of 0, which would make 100 a plausible high value for this test. For the plausible low level, this study 3 discusses patients with an HDL level less than 20 mg/dl and triglycerides greater than 500 mg/dl, which would result in a value of at most 4. Given that, a plausible low value of 1 does not seem unreasonable.

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