3033575

3033575 - Monocytes [#/volume] in Blood by Automated count

A monocyte is a mononuclear leukocyte, intimately involved in the initiaton of an immune response. It also protects against blood-borne pathogens and migrates quickly to sites of infection in the tissues. Monocytes are usually identified in stained smears by their large bilobed nucleus. They are produced by the bone marrow from hematopoietic stem cell precursors called monoblasts. The monoblast is the first stage of monocyte maturation. The developmental stages (4 subtypes) of the monocytes are: monoblast, promonocyte, immature monocyte, and mature monocyte. 1

8647

In the OMOP vocabulary 8647 is a Standard Concept that represents the unit per microliter (/uL)

Plausible Low Value

0

Plausible High Value

3,000.00

Rationale

Depending on the age of the adult, monocytes can make up 0 to 10% of circulating white blood cells and can range from 0/uL to 950/uL 2, 3, 4. For children, monocytes can be as high as 3000/uL. This information combined with a data-driven approach to empirically establish possible low and high values, leads us to choose 0 and 3,000.